Maxillary sinus elevation surgery with chronos and autogenous bone graft: immunohistochemical assessment of RUNX2, VEGF, TRAP, and osteocalcin

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dc.creatorRodrigodos Santos Pereira
dc.creatorFernanda Brasil Daura Jorge Boos Lima
dc.creatorLuis Fernando de Oliveira Gorla
dc.creatorIdelmo Rangel Garcia Júnior
dc.creatorRoberta Okamoto Canesin
dc.creatorEduardo Hochuli-Vieira
dc.date.accessioned2025-06-23T22:33:58Z
dc.date.accessioned2025-09-09T00:06:10Z
dc.date.available2025-06-23T22:33:58Z
dc.date.issued2017-10-17
dc.format.mimetypepdf
dc.identifier.issn1945-3388
dc.identifier.urihttps://hdl.handle.net/1843/83092
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Periodontics & Restorative Dentistry
dc.rightsAcesso Restrito
dc.subjectOsteogenesis
dc.subjectCell self renewal
dc.subjectBone transplantation
dc.subjectBlood
dc.subjectHistology
dc.subjectImmunohistochemistry
dc.subjectCore Binding Factor Alpha 2 subunit
dc.subjectVascular Endothelial Growth Factor A
dc.subjectEvaluation study
dc.subjectCore Binding Factor Alpha subunits
dc.subjectTartrate-resistant acid phosphatase
dc.subjectColor
dc.subjectImmune system
dc.subjectOsteocalcin
dc.titleMaxillary sinus elevation surgery with chronos and autogenous bone graft: immunohistochemical assessment of RUNX2, VEGF, TRAP, and osteocalcin
dc.typeArtigo de periódico
local.citation.epage327
local.citation.issue6
local.citation.spage321
local.citation.volume37
local.description.resumoThe purpose of this study was to evaluate a composite graft of ChronOS, a betatricalcium phosphate (β-TCP), mixed 1:1 with an autogenous bone graft in human maxillary sinus augmentation. A total of 12 maxillary sinuses were grafted with an autogenous bone graft (control group), and 9 maxillary sinuses were grafted with ChronOS mixed 1:1 with an autogenous bone graft (test group). After 6 months, biopsy samples were obtained concurrent to the placement of dental implants and were subjected to histomorphometric and immunohistochemical analyses for Runtrelated transcription factor 2 (RUNX2), vascular endothelial growth factor (VEGF), tartrate-resistant acid phosphatase, and osteocalcin. Histologic analysis of samples obtained from the test group revealed the presence of immature bone, while samples from the control group indicated lamellar bone formation. However, both types of bone grafts were well vascularized. The new bone formation averaged 25.4% ± 6.4% in the test group and 38.6% ± 10.5% in the control group (P = .001). Immunostaining of samples in the test group showed high cellular turnover. The outcomes of this study demonstrate a delay in bone formation but intense cellular differentiation after 6 months of bone graft healing in the test group. The amount of immature bone and the immunostaining for RUNX2 and VEGF provide evidence of an osteogenic pathway that can improve the bone formation rate.
local.identifier.orcidhttps://orcid.org/0000-0003-2509-8633
local.identifier.orcidhttps://orcid.org/0000-0003-2847-9685
local.identifier.orcidhttps://orcid.org/0000-0003-2115-1898
local.identifier.orcidhttps://orcid.org/0009-0006-3690-8936
local.identifier.orcidhttps://orcid.org/0000-0002-6773-6966
local.identifier.orcidhttps://orcid.org/0000-0003-4040-9313
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.quintessence-publishing.com/deu/en/article/854224/international-journal-of-periodontics-restorative-dentistry/2017/06/maxillary-sinus-elevation-surgery-with-chronos-and-autogenous-bone-graft-immunohistochemical-assessment-of-runx2-vegf-trap-and-osteocalcin

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