Assessing photosensitized membrane damage: available tools and comprehensive mechanisms

dc.creatorLaura Gonçalves Rezende
dc.creatorThiago Teixeira Tasso
dc.creatorPedro H. S. Cândido
dc.creatorMauricio da Silva Baptista
dc.date.accessioned2023-10-27T12:54:34Z
dc.date.accessioned2025-09-08T23:01:22Z
dc.date.available2023-10-27T12:54:34Z
dc.date.issued2022
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1111/php.13582
dc.identifier.issn1751-1097
dc.identifier.urihttps://hdl.handle.net/1843/60146
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhotochemistry and Photobiology
dc.rightsAcesso Restrito
dc.subjectLipídios
dc.subjectLipídios - oxidação
dc.subjectFotoquímica orgânica
dc.subjectAnálise espectral
dc.subjectMicroscopia
dc.subjectBioquímica
dc.subject.otherLipids
dc.subject.otherLipid oxidation
dc.subject.otherMicroscopy
dc.subject.otherPhotosensitized oxidation
dc.subject.otherSpectroscopy
dc.subject.otherCellular assays
dc.titleAssessing photosensitized membrane damage: available tools and comprehensive mechanisms
dc.typeArtigo de periódico
local.citation.epage590
local.citation.issue3
local.citation.spage572
local.citation.volume98
local.description.resumoLipids are important targets of the photosensitized oxidation reactions, forming important signaling molecules, disorganizing and permeabilizing membranes, and consequently inducing a variety of biological responses. Although the initial steps of the photosensitized oxidative damage in lipids are known to occur by both Type I and Type II mechanisms, the progression of the peroxidation reaction, which leads to important end-point biological responses, is poorly known. There are many experimental tools used to study the products of lipid oxidation, but neither the methods nor their resulting observations were critically compared. In this article, we will review the tools most frequently used and the key concepts raised by them in order to rationalize a comprehensive model for the initiation and the progression steps of the photoinduced lipid oxidation.
local.identifier.orcidhttps://orcid.org/0000-0002-9636-7792
local.identifier.orcidhttps://orcid.org/0000-0001-9362-9227
local.identifier.orcidhttps://orcid.org/0000-0001-7079-7666
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/php.13582

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