Antioxidant activity and cytotoxicity effect of cocoa beans subjected to different processing conditions in human lung carcinoma cells

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dc.creatorDeborah de Almeida Bauer Guimarães
dc.creatorJoel Pimentel de Abreu
dc.creatorHilana Salete Silva Oliveira
dc.creatorAristóteles Góes Neto
dc.creatorMaria Gabriela Bello Koblitz
dc.creatorAnderson Junger Teodoro
dc.date.accessioned2023-06-15T21:26:20Z
dc.date.accessioned2025-09-09T00:18:19Z
dc.date.available2023-06-15T21:26:20Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2016/7428515
dc.identifier.issn1942-0994
dc.identifier.urihttps://hdl.handle.net/1843/54977
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.rightsAcesso Aberto
dc.subjectAntioxidantes
dc.subjectCacau
dc.subjectNeoplasias Pulmonares
dc.subject.otherAntioxidant activity
dc.subject.otherCocoa Beans
dc.subject.otherLung cancer
dc.subject.otherCarcinoma cells
dc.titleAntioxidant activity and cytotoxicity effect of cocoa beans subjected to different processing conditions in human lung carcinoma cells
dc.title.alternativeAtividade antioxidante e efeito citotóxico de grãos de cacau submetidos a diferentes condições de processamento em célula de carcinoma de pulmão humano
dc.typeArtigo de periódico
local.citation.volume2016
local.description.resumoLung cancer is a common malignancy in men and the second leading cause of cancer-related mortality in men in the western world. Phenolic cocoa ingredients have a strong antioxidative activity and the potential to have a protective effect against cancer. In the present study, we have evaluated the influence of cocoa beans subjected to different processing conditions on cell viability and apoptosis of human lung cancer cells (A549). We measured the viability of lung cells treated with cocoa beans, unroasted slates (US), roasted slates (RS), unroasted well fermented (UWF) cocoa, and roasted well fermented (RWF) cocoa for 24 h. Using an MTT assay, we observed a decrease in the viability of A549 cells after treatment with cocoa bean extracts. Flow cytometer analysis revealed that cocoa beans increased the percentage of cells in sub-G1 phase and promoted up to twofold increase of apoptotic cells when compared to the control group. Taken together, the present study suggests that cocoa beans may have a protective effect against lung cancer.
local.identifier.orcidhttps://orcid.org/0000-0002-9714-9674
local.identifier.orcidhttps://orcid.org/0000-0003-2994-7823
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.identifier.orcidhttps://orcid.org/0000-0002-5558-570X
local.identifier.orcidhttps://orcid.org/0000-0002-0949-9528
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/omcl/2016/7428515/

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