Angiotensin-(1-7), adipokines and inflammation

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dc.creatorDeborah de Farias Lelis
dc.creatorDaniela Fernanda de Freitas
dc.creatorAmanda Souto Machado
dc.creatorThaísa Soares Crespo
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-30T13:30:15Z
dc.date.accessioned2025-09-08T23:45:35Z
dc.date.available2022-08-30T13:30:15Z
dc.date.issued2019-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1016/j.metabol.2019.03.006
dc.identifier.issn0026-0495
dc.identifier.urihttps://hdl.handle.net/1843/44695
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMetabolism
dc.rightsAcesso Restrito
dc.subjectSistema renina-angiotensina
dc.subjectEnzima conversora da angiotensina
dc.subjectTecido adiposo
dc.subjectInflamação
dc.subjectHomeostase
dc.subjectObesidade
dc.subjectDiabetes
dc.titleAngiotensin-(1-7), adipokines and inflammation
dc.typeArtigo de periódico
local.citation.epage45
local.citation.spage36
local.citation.volume19
local.description.resumoNowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses angiotensin-(1–7), which is now recognized as the main peptide on counteracting Ang II effects. New studies have shown that increased activation of ACE2/Ang-(1–7)/MasR arm can revert and prevent local and systemic dysfunctions improving lipid profile and insulin resistance by modulating insulin actions, and reducing inflammation. In this context, the present review shows the interaction and relevance of Ang-(1–7) effects on regulating adipokines, and as one adipokine itself, modulating body homeostasis, with emphasis on its anti-inflammatory properties, especially in the context of metabolic disorders with focus on obesity and type 2 diabetes mellitus pandemic.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0026049519300629?via%3Dihub

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