Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: a randomized controlled trial

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dc.creatorValdir de Aquino Lemos
dc.creatorRonaldo Vagner Thomatieli dos Santos
dc.creatorHanna Karen Moreira Antunes
dc.creatorClaus Behn
dc.creatorGinés Viscor
dc.creatorFabio Santos Lira
dc.creatorIrene Guarido Luz Bittar
dc.creatorAline Venticinque Caris
dc.creatorSergio Tufik
dc.creatorMarco Tulio De Mello
dc.date.accessioned2023-03-31T16:34:59Z
dc.date.accessioned2025-09-08T22:59:35Z
dc.date.available2023-03-31T16:34:59Z
dc.date.issued2018-11
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.physbeh.2018.08.016
dc.identifier.issn0031-9384
dc.identifier.urihttps://hdl.handle.net/1843/51442
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhysiology & Behavior
dc.rightsAcesso Restrito
dc.subjectHipóxia
dc.subjectExercícios físicos
dc.subjectMelatonina
dc.subject.otherHypoxia
dc.subject.otherExercise
dc.subject.otherMelatonin
dc.titleMelatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: a randomized controlled trial
dc.typeArtigo de periódico
local.citation.epage103
local.citation.spage95
local.citation.volume196
local.description.resumoThis work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal iThis work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal increase in melatonin was inversely correlated with the oxygen saturation of hemoglobin (SaO2%) on the 2nd night in the H group and on the 2nd day in the EH group. Diurnal remission of nocturnal melatonin appeared to be postponed in the H group and even more so in the EH group. Thus, normobaric hypoxia, which is equivalent to oxygen availability at an altitude of 4500 m, acutely increases melatonin. Moreover, diurnal remission of the nocturnal increase in melatonin seems to be delayed by hypoxia alone but even more so when acting together with exercise.
local.identifier.orcidhttps://orcid.org/0000-0001-9974-0049
local.identifier.orcidhttps://orcid.org/0000-0001-7010-2799
local.identifier.orcidhttps://orcid.org/0000-0001-6648-0957
local.identifier.orcidhttps://orcid.org/0000-0003-4942-2346
local.identifier.orcidhttps://orcid.org/0000-0002-9645-1003
local.identifier.orcidhttps://orcid.org/0000-0002-9314-3195
local.identifier.orcidhttps://orcid.org/0000-0002-4012-495
local.identifier.orcidhttps://orcid.org/0000-0003-3896-2208
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0031938418306942

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