Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

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dc.creatorBernardo Carvalho Dutra
dc.creatorAlcione Maria Soares Dutra de Oliveira
dc.creatorPeterson Antonio Dutra de Oliveira
dc.creatorFlávio Ricardo Manzi
dc.creatorSheila Cavalca Cortelli
dc.creatorLuis Otávio de Miranda Cota
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2024-06-04T17:24:21Z
dc.date.accessioned2025-09-09T01:05:09Z
dc.date.available2024-06-04T17:24:21Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2016-0252
dc.identifier.issn16787757
dc.identifier.urihttps://hdl.handle.net/1843/68805
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Oral Science
dc.subjectAlendronate
dc.subjectSodium
dc.subjectPeriodontitis
dc.subjectDental scaling
dc.subjectBone and bones
dc.subjectCone-beam computed tomography
dc.subject.otheralendronate sodium
dc.subject.otherintraosseus defects
dc.subject.othernon-surgical periodontal therapy
dc.subject.otherPeriodontitis Sodium; alendronate; Biphosphonates; Periodontitis; Dental scaling
dc.titleEffect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial
dc.typeArtigo de periódico
local.citation.epage317
local.citation.issue3
local.citation.spage310
local.citation.volume25
local.description.resumoBackground and objectives: Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and methods: Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05). Results: Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jaos/a/FfxBKfPv8JkJx9QwdgSjdNh/?lang=en

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