Oral pyogenic granulomas show MAPK/ERK signaling pathway activation, which occurs independently of BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations

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dc.creatorThaís dos Santos Fontes Pereira
dc.creatorLarissa Stefhanne Damasceno de Amorim Póvoa
dc.creatorNubia Braga Pereira
dc.creatorJéssica Gardone Vitório
dc.creatorFilipe Fideles Duarte'andrade
dc.creatorLetícia Martins Guimarães
dc.creatorMarina Gonçalves Diniz
dc.creatorCarolina Cavaliéri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-08-08T20:03:56Z
dc.date.accessioned2025-09-08T23:23:07Z
dc.date.available2025-08-08T20:03:56Z
dc.date.issued2019-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12922
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/84218
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectMitogen-activated protein kinases
dc.subjectHemangioma, capillary
dc.subjectOncogenes
dc.subjectGranuloma, pyogenic
dc.subjectGenes
dc.subjectImmunohistochemistry
dc.subjectMitogen-activated protein kinase kinases
dc.subject.otherMAPK
dc.subject.otherRAS
dc.subject.otherCapillary hemangioma
dc.subject.otherOncogene
dc.subject.otherPyogenic granuloma
dc.titleOral pyogenic granulomas show MAPK/ERK signaling pathway activation, which occurs independently of BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations
dc.typeArtigo de periódico
local.citation.epage910
local.citation.issue10
local.citation.spage906
local.citation.volume48
local.description.resumoBackground: Pyogenic granuloma (PG) is a benign nodular lesion with a prominent vascular component which may affect different sites. Recently, BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations were reported on PGs of the skin. The present study assessed the role of the MAPK/ERK pathway in oral PG pathogenesis. Methods: Mutations in hotspot regions of genes involved in the MAPK/ERK pathway activation were investigated by Sanger sequencing. The expression of phospho-ERK1/2 was evaluated by immunohistochemistry. Results: Oral PGs did not show mutations in the sequenced regions of the genes BRAF, KRAS, HRAS, NRAS, GNA11, or GNA14. Our results also showed activation of the MAPK/ERK pathway demonstrated by phospho-ERK1/2 immunohistochemical positivity. Conclusions: Although oral PG shows MAPK/ERK pathway activation, the driver molecular event remains to be elucidated.
local.identifier.orcidhttps://orcid.org/0000-0003-1221-1326
local.identifier.orcidhttps://orcid.org/0000-0002-6714-3124
local.identifier.orcidhttps://orcid.org/0000-0002-5009-6675
local.identifier.orcidhttps://orcid.org/0000-0003-0345-0376
local.identifier.orcidhttps://orcid.org/0000-0002-1022-0336
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12922

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