Preparation and characterization of gadolinium-based thermosensitive liposomes: a potential nanosystem for selective drug delivery to cancer cells

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dc.creatorAna Luiza Chaves Maia
dc.creatorAndré Luís Branco de Barros
dc.creatorDaniel Crístian Ferreira Soares
dc.creatorGilson Andrade Ramaldes
dc.creatorAline Teixeira Maciel e Silva
dc.creatorAina Liz Alves Cesar
dc.creatorFernanda Cristina Gontijo Evangelista
dc.creatorJanaína de Alcântara Lemos
dc.creatorAdriano de Paula Sabino
dc.creatorÂngelo Malachias de Souza
dc.creatorChristian Fernandes
dc.creatorCristiane dos Santos Giuberti
dc.date.accessioned2023-04-26T17:16:04Z
dc.date.accessioned2025-09-08T23:17:56Z
dc.date.available2023-04-26T17:16:04Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.jddst.2021.102686
dc.identifier.issn2588-8943
dc.identifier.urihttps://hdl.handle.net/1843/52518
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.rightsAcesso Restrito
dc.subjectLipossomos
dc.subjectCâncer
dc.subject.otherGadodiamide
dc.subject.otherThermosensitive liposomes
dc.subject.otherLiposome characterization
dc.subject.otherDrug delivery
dc.subject.otherCytotoxic activity
dc.titlePreparation and characterization of gadolinium-based thermosensitive liposomes: a potential nanosystem for selective drug delivery to cancer cells
dc.typeArtigo de periódico
local.citation.epage15
local.citation.spage1
local.citation.volume65
local.description.resumoGadodiamide (Gd-DTPA-BMA) is a gadolinium-based complex, used as a contrast agent in magnetic resonance imaging procedures. Recent studies revealed the capacity of this complex of inducing apoptosis in neoplastic cells. However, a great challenge for its use as an anticancer drug is low cellular internalization and drug delivery systems such as thermosensitive liposomes can be a strategy to overcome these limitations and increase anti-tumor efficacy. In this context, this study aimed to develop, characterize, and assess the cytotoxic activity and selectivity index of thermosensitive liposomes containing Gd-DTPA-BMA. Formulations were prepared by the lipid film hydration method and their physicochemical, morphological, and thermal properties were evaluated. Cell viability was performed 4T1/MDA-MB-231 tumor cells and WI-26 VA4 normal cells. Transmission electron microscopy analyses showed high electron density in the inner core of Gd-DTPA-BMA-loaded liposomes that can be attributed to the Gd-DTPA-BMA, since Gd-loaded nanosystems present low light transmittance and high electron density by this technique. The dynamic light scattering, differential scanning calorimetry, small-angle X-ray scattering, and in vitro release results confirm that the lipid composition was suitable since Tc (temperature of the transition Lβ → Lα) values are in accordance with those reported for thermosensitive liposomes used in the treatment of cancer. The cytotoxic studies against breast cancer cell lines demonstrated that the Gd-DTPA-BMA-loaded liposomes have higher cytotoxicity than free Gd-DTPA-BMA. Moreover, these liposomes presented minimal toxicity in a normal cell line when compared to the free Gd-DTPA-BMA. Therefore, the results of this study suggest that thermosensitive liposomes containing Gd-DTPA-BMA might be a new promising nanocarrier system for breast cancer treatment.
local.identifier.orcidhttps://orcid.org/0000-0002-7641-6585
local.identifier.orcidhttps://orcid.org/0000-0002-2204-6881
local.identifier.orcidhttps://orcid.org/0000-0002-8067-1810
local.identifier.orcidhttps://orcid.org/0000-0001-8458-0097
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0002-3905-3674
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8731
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S177322472100366X

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