Resolution of inflammation: what controls its onset?

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dc.creatorMichelle Adriane Amantéa Sugimoto
dc.creatorLirlândia Pires de Sousa
dc.creatorVanessa Pinho
dc.creatorMauro Perretti
dc.creatorMauro Martins Teixeira
dc.date.accessioned2023-03-24T21:09:20Z
dc.date.accessioned2025-09-09T01:20:44Z
dc.date.available2023-03-24T21:09:20Z
dc.date.issued2016-04-26
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.3389/fimmu.2016.00160
dc.identifier.issn16643224
dc.identifier.urihttps://hdl.handle.net/1843/51225
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectInflamação
dc.subject.otherResolution
dc.subject.otherChemokine depletion
dc.subject.otherEicosanoids
dc.subject.otherPro-resolving mediators
dc.subject.otherTissue homeostasis
dc.titleResolution of inflammation: what controls its onset?
dc.typeArtigo de periódico
local.citation.epage18
local.citation.spage1
local.citation.volume7
local.description.resumoAn effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses begin. In this context, several mechanisms provide the fine-tuning of inflammation and create a favorable environment for the resolution phase to take place and for homeostasis to return. In this review, we focus on the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution. We suggest that several mediators that promote the inflammatory phase of inflammation can simultaneously initiate a program for active resolution. Indeed, several events enact a decrease in the local chemokine concentration, a reduction which is essential to inhibit further infiltration of neutrophils into the tissue. Interestingly, although neutrophils are cells that characteristically participate in the active phase of inflammation, they also contribute to the onset of resolution. Further understanding of the molecular mechanisms that initiate resolution may be instrumental to develop pro-resolution strategies to treat complex chronic inflammatory diseases, in humans. The efforts to develop strategies based on resolution of inflammation have shaped a new area of pharmacology referred to as “resolution pharmacology.”
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fimmu.2016.00160/full

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