High CD3+ lymphocytes, low CD66b+ neutrophils, and scarce tumor budding in the invasive front of lip squamous cell carcinomas

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dc.creatorKarine Duarte da Silva
dc.creatorPatrícia Carlos Caldeira
dc.creatorAlessandro Menna Alves
dc.creatorAna Carolina Uchoa Vasconcelos
dc.creatorAna Paula Neutzling Gomes
dc.creatorMaria Cássia Ferreira Aguiar
dc.creatorSandra Beatriz Chaves Tarquinio
dc.date.accessioned2024-09-05T19:40:12Z
dc.date.accessioned2025-09-08T23:17:00Z
dc.date.available2024-09-05T19:40:12Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2019.05.027
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/75978
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Aberto
dc.subjectCarcinoma, squamous cell
dc.subjectLip neoplasms
dc.subjectNeutrophils
dc.subjectLymphocytes
dc.subjectT-lymphocytes
dc.subjectImmunohistochemistry
dc.subjectCD3 complex
dc.subjectInflammation
dc.subject.otherSquamous cell carcinoma
dc.titleHigh CD3+ lymphocytes, low CD66b+ neutrophils, and scarce tumor budding in the invasive front of lip squamous cell carcinomas
dc.typeArtigo de periódico
local.citation.epage51
local.citation.issueArchives of Oral Biology assunto fao clínica assunto Carcinoma de Células Escamosas
local.citation.spage46
local.citation.volume104
local.description.resumoObjective This study aimed to evaluate tumor budding (TB) and quantify the neutrophilic and lymphocytic infiltration in the invasive front of lip squamous cell carcinomas. In addition, the associations between these features and the histopathological grading in the invasive front were analyzed. Design A total of 43 lip squamous cell carcinoma surgical specimens were included and classified in accordance with a histological invasive front grading system. Immunohistochemistry was performed for CD66b and CD3 for the evaluation of neutrophils and T lymphocytes, respectively, in the invasive front of the tumors. Tumor budding was evidenced by AE1/AE3 staining. Results Thirty-six (83.7%) of the tumors were well-differentiated tumors. Eleven (25.6%) of the cases exhibited high-intensity tumor budding. There were low neutrophil and high T lymphocyte infiltrations in the invasive front, leading to a low neutrophil/T lymphocyte ratio in the same region. Moreover, we found an association between tumor budding and the pattern of invasion, and between the CD3+ cell count and the inflammatory infiltrate (p < 0.05). Conclusions The low neutrophil and high T lymphocyte infiltration in the invasive front, and the few high-intensity tumor budding cases are in accordance with the histopathological features of well-differentiated lip tumors. If these characteristics remain in lip squamous cell carcinomas with more aggressive histopathological features, it deserves to be investigated.
local.identifier.orcidhttps://orcid.org/0000-0001-9273-376X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996919301281

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