Effect of the extract and constituents from Hancornia speciosa fruits in osteoclasts

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dc.creatorMicena Roberta Miranda Alves e Silva
dc.creatorCinthia Mara da Fonseca Pacheco
dc.creatorMila Fernandes Moreira Madeira
dc.creatorAdriana Machado Saraiva
dc.creatorElisângela Alves de Freitas
dc.creatorThalita Marcolan Valverde
dc.creatorJosé Hugo de Sousa Gomes
dc.creatorRodrigo Maia de Pádua
dc.creatorGregory Thomas Kitten
dc.creatorSandra Yasuyo Fukada Alves
dc.creatorFernão Castro Braga
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-04-28T13:33:07Z
dc.date.accessioned2025-09-09T01:29:29Z
dc.date.available2025-04-28T13:33:07Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1055/a-0829-0454
dc.identifier.issn2509-6656
dc.identifier.urihttps://hdl.handle.net/1843/81917
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPlanta medica international
dc.rightsAcesso Aberto
dc.subjectOsteoclasts
dc.subjectBone resorption
dc.subjectCell culture techniques
dc.subjectApocynaceae
dc.subjectOsteogenesis
dc.subject.otherHancornia speciosa
dc.subject.otherApocynaceae
dc.subject.otherCell culture
dc.subject.otherOsteoclasts
dc.subject.otherBone resorption
dc.titleEffect of the extract and constituents from Hancornia speciosa fruits in osteoclasts
dc.typeArtigo de periódico
local.citation.epagee14
local.citation.issue01
local.citation.spagee7
local.citation.volume6
local.description.resumoHancornia speciosa is a medicinal species traditionally used in Brazilian folk medicine to treat a variety of conditions. Compounds isolated from the leaves, bark, and trunk of this plant have shown therapeutic properties, but only recently have the fruits of H. speciosa been explored for potential pharmacological applications. The present study investigated the effects of an ethanolic extract from the fruits, fractions, and compounds thereof in bone resorbing cells. Primary osteoclast cultures from bone marrow cells and osteoclasts derived from a monocyte/macrophage cell line, RAW 264.7, were incubated with different concentrations of the ethanolic extract, ethyl acetate fraction, water fraction, quinic acid, and L-(+)-bornesitol. In RAW 264.7 cell cultures, quinic acid significantly reduced osteoclast formation. In bone marrow cell-derived osteoclasts, the ethyl acetate fraction induced a decrease in the number of osteoclasts, promoting a remarkable reduction in the mean area of those cells and in their resorption activity. The compounds quinic acid and bornesitol also affected bone marrow cell-derived osteoclasts. In both cell cultures, the substances tested did not affect cell viability/proliferation. In conclusion, components extracted from H. speciosa fruit affected the cells responsible for bone resorption, making them promising tools for interference in osteoclastogenesis.
local.identifier.orcidhttps://orcid.org/0000-0002-6642-3650
local.identifier.orcidhttps://orcid.org/0000-0001-9468-376X
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0009-0001-2072-5282
local.identifier.orcidhttps://orcid.org/0000-0003-2437-5707
local.identifier.orcidhttps://orcid.org/0000-0002-9939-6900
local.identifier.orcidhttps://orcid.org/0000-0002-4044-9932
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0002-6589-4784
local.identifier.orcidhttps://orcid.org/0000-0002-0986-0184
local.identifier.orcidhttps://orcid.org/0000-0002-7910-8975
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0829-0454

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