Triggering different brain states using asynchronous serial communication to the rat amygdala

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dc.creatorFlávio Afonso Gonçalves Mourão
dc.creatorAndré Luiz Vieira Lockmann
dc.creatorGabriel Perfeito Castro
dc.creatorDaniel de Castro Medeiros
dc.creatorMarina Pádua Reis
dc.creatorGrace Schenatto Pereira Moraes
dc.creatorAndré Ricardo Massensini
dc.creatorMarcio Flávio Dutra Moraes
dc.date.accessioned2023-07-14T20:31:27Z
dc.date.accessioned2025-09-08T22:49:05Z
dc.date.available2023-07-14T20:31:27Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.1093/cercor/bhu313
dc.identifier.issn1047-3211
dc.identifier.urihttps://hdl.handle.net/1843/56295
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCerebral Cortex
dc.rightsAcesso Aberto
dc.subjectAmigdalas
dc.subjectMedo
dc.subject.otherAmygdaloid complex
dc.subject.otherElectrical microstimulation
dc.subject.otherFear-conditioning
dc.subject.otherPrefrontal cortex
dc.subject.otherTemporal coding
dc.titleTriggering different brain states using asynchronous serial communication to the rat amygdala
dc.typeArtigo de periódico
local.citation.epage1877
local.citation.issue5
local.citation.spage1866
local.citation.volume26
local.description.resumoInputting information to the brain through direct electrical microstimulation must consider how underlying neural networks encode information. One unexplored possibility is that a single electrode delivering temporally coded stimuli, mimicking an asynchronous serial communication port to the brain, can trigger the emergence of different brain states. This work used a discriminative fear-conditioning paradigm in rodents in which 2 temporally coded microstimulation patterns were targeted at the amygdaloid complex. Each stimulus was a binary-coded “word” made up of 10 ms bins, with 1's representing a single pulse stimulus: A-1001111001 and B-1110000111. During 3 consecutive retention tests (i.e., day-word: 1-B; 2-A, and 3-B), only binary-coded words previously paired with a foot-electroshock elicited proper aversive behavior. To determine the neural substrates recruited by the different stimulation patterns, c-Fos expression was evaluated 90 min after the last retention test. Animals conditioned to word-B, after stimulation with word-B, demonstrated increased hypothalamic c-Fos staining. Animals conditioned to word-A, however, showed increased prefrontal c-Fos labeling. In addition, prefrontal-cortex and hypothalamic c-Fos staining for, respectively, word-B- and word-A-conditioned animals, was not different than that of an unpaired control group. Our results suggest that, depending on the valence acquired from previous learning, temporally coded microstimulation activates distinct neural networks and associated behavior.
local.identifier.orcidhttps://orcid.org/0000-0002-4519-3585
local.identifier.orcidhttps://orcid.org/0000-0002-1456-4689
local.identifier.orcidhttps://orcid.org/0000-0003-0243-1309
local.identifier.orcidhttps://orcid.org/0000-0002-2170-6649
local.identifier.orcidhttps://orcid.org/0000-0002-1508-3801
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/cercor/article/26/5/1866/1753715?login=true

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