Avaliação de biomarcadores inflamatórios em artérias pulmonares de transplantados cardíacos chagásicos e não chagásicos

Abstract

In Brazil, Chagas cardiomyopathy is the third most common cause of indication for heart transplantation (HTx). Pulmonary arterial hypertension (PAH) is a severe condition frequently present in patients with terminal heart failure that worsens the prognosis of patients undergoing HTx. The etiological mechanism of PAH is multifactorial, with increased ventricular filling pressure being one of the main ones. Recently, however, several studies have sought to demonstrate the role of the local in ammatory process in contributing to the sti ening of the pulmonary arteries and the emergence or worsening of PAH in the heart failure (HF) setting. Objectives: To evaluate the in ammatory process in the pulmonary arteries of chagasic HTx (HTx-C) and non-chagasic (HTx-NC) patients, with and without PAH, through the tissue concentration of in ammatory cytokines obtained at the time of HTx. Methods: e levels of interleukins (IL) 6, IL-1β, TNF-α, and CD68 and CD66b neutrophils were measured in fragments of the pulmonary arteries of HTx-C and HTx-NC patients with and without PAH. Results: No statistically signi cant di erence (p ≥ 0.05) between the in ammatory biomarkers measured in HTx-C and HTx-NC pulmonary arteries, with or without PAH. Conclusion: We observed that HTx-C and HTx-NC patients present the same levels of in ammatory markers expressed in the pulmonary artery tissue, whether or not they have PAH. is fact suggests that PAH in HTx-C and HTx-NC patients is a process that is related to HF itself and not to the patients’ inflammatory profile.