Cytotoxic activity of triterpenoids from Cheiloclinium cognatum branches against chronic and acute leukemia cell lines

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dc.creatorRafael César Gonçalves Pereira
dc.creatorFernanda Cristina Gontijo Evangelista
dc.creatorValtair Severino dos Santos Júnior
dc.creatorAdriano de Paula Sabino
dc.creatorVinícius Gonçalves Maltarollo
dc.creatorRossimiriam Pereira de Freitas
dc.creatorLucienir Pains Duarte
dc.date.accessioned2024-07-15T18:39:19Z
dc.date.accessioned2025-09-09T01:30:23Z
dc.date.available2024-07-15T18:39:19Z
dc.date.issued2020
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1002/cbdv.202000773
dc.identifier.issn1612-1880
dc.identifier.urihttps://hdl.handle.net/1843/70587
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemistry & Biodiversity
dc.rightsAcesso Restrito
dc.subjectQuímica vegetal
dc.subjectAgentes antineoplásicos
dc.subjectLeucemia
dc.subjectApoptose
dc.subjectQuimiometria
dc.subjectCelastraceae
dc.subjectTerpenios
dc.subject.otherTriterpenoids
dc.subject.otherCheiloclinium cognatum
dc.subject.otherCelastraceae
dc.subject.otherAcute leukemia
dc.subject.otherChronic leukemia
dc.titleCytotoxic activity of triterpenoids from Cheiloclinium cognatum branches against chronic and acute leukemia cell lines
dc.typeArtigo de periódico
local.citation.issue12
local.citation.spagee2000773
local.citation.volume17
local.description.resumoCheiloclinium cognatum (Miers) A.C.Sm. is an endemic species of Brazilian Cerrado that belongs to Celastraceae family. The phytochemical study of C. cognatum branches led to the identification of ten triterpenoids (TPs), 3β-acyloxyurs-12-ene (1), friedelin (2), β-friedelinol (3), glut-5-en-3β-ol (4), α-amyrin (5), β-amyrin (6), β-sitosterol (7), canophyllol (8), 29-hydroxyfriedelan-3-one (9) and friedelane-3β,29-diol (10). TPs 4, 5 and 6 are described for the first Cheiloclinium genus and TPs 8 and 9 were isolated in expressive amounts. Their cytotoxic activities were evaluated against THP-1 and K562 leukemia cell lines. TPs 3 and 5 were the most active, exhibiting lower or similar IC50 against both cell lines when compared to the controls. Their mechanisms of action were investigated suggesting an intrinsic mitochondrial pathway of apoptosis evidenced by up-regulation of BAK mRNA expression. Chemometric studies indicated that their activities may be related to their molecular size and shape as well as electronic interactions of C-3 hydroxy group with molecular targets.
local.identifier.orcidhttps://orcid.org/0000-0003-1600-7621
local.identifier.orcidhttps://orcid.org/0000-0003-4682-397X
local.identifier.orcidhttps://orcid.org/0000-0002-4291-8624
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.identifier.orcidhttps://orcid.org/0000-0001-9675-5907
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.identifier.orcidhttps://orcid.org/0000-0002-8885-6625
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000773

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