Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis

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dc.creatorJeanne Brenda Martins
dc.creatorVanessa Amaral Mendonça
dc.creatorGrazielle Cordeiro Aguiar
dc.creatorSueli Ferreira da Fonseca
dc.creatorJousielle Márcia dos Santos
dc.creatorRosalina Tossige Gomes
dc.creatorDirceu de Sousa Melo
dc.creatorMurilo Xavier Oliveira
dc.creatorHércules Ribeiro Leite
dc.creatorAna Cristina Resende Camargos
dc.creatorAnderson José Ferreira
dc.creatorCândido Celso Coimbra
dc.creatorJacques Poortmans
dc.creatorVinícius Cunha Oliveira
dc.creatorSara Barros Silva
dc.creatorTalita Emanuela Domingues
dc.creatorMario Bernardo Filho
dc.creatorAna Cristina Rodrigues Lacerda
dc.date.accessioned2022-06-22T14:28:39Z
dc.date.accessioned2025-09-08T23:32:38Z
dc.date.available2022-06-22T14:28:39Z
dc.date.issued2019-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fphys.2019.01168
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/1843/42594
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Physiology
dc.rightsAcesso Aberto
dc.subjectOsteoartrite
dc.subjectExercícios aeróbicos
dc.subjectBiomarcadores
dc.subjectArticulações - Aspectos fisiológicos
dc.subjectRatos
dc.subject.otherOsteoarthritis
dc.subject.otherAerobic training
dc.subject.otherExercise
dc.subject.otherBiomarkers
dc.subject.otherJoint function
dc.titleEffect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue1168
local.citation.spage1
local.citation.volume10
local.description.resumoBackground: Knee osteoarthritis (kOA) is a common chronic disease that induces changes in redox status and inflammatory biomarkers, cell death, and motor impairment. Aerobic training can be a non-pharmacological alternative to prevent the progression of the disease. Objective: To evaluate the effects of an 8 weeks moderate-intensity treadmill aerobic training program on redox status and inflammatory biomarkers and motor performance in kOA-like changes induced by monosodium iodoacetate (MIA) in rats. Methods: Twenty-seven rats were randomly divided into three groups: SHAM; induced kOA (OA); and induced kOA + aerobic training (OAE). Motor performance was evaluated by the number of falls on rotarod test, the total time of displacement and the number of failures on a 100 cm footbridge. Data for cytokines and histology were investigated locally, whereas plasma was used for redox status biomarkers. Results: The OA group, compared to the SHAM group, increased 1.13 times the total time of displacement, 6.05 times the number of failures, 2.40 times the number of falls. There was also an increase in cytokine and in thiobarbituric acid reactive substances (TBARS) (IL1β: 5.55-fold, TNF: 2.84-fold, IL10: 1.27-fold, IL6: 1.50-fold, TBARS: 1.14-fold), and a reduction of 6.83% in the total antioxidant capacity (FRAP), and of 35% in the number of chondrocytes. The aerobic training improved the motor performance in all joint function tests matching to SHAM scores. Also, it reduced inflammatory biomarkers and TBARS level at values close to those of the SHAM group, with no change in FRAP level. The number of falls was explained by IL1β and TNF (58%), and the number of failures and the total time of displacement were also explained by TNF (29 and 21%, respectively). Conclusion: All findings indicate the efficacy of moderate-intensity aerobic training to regulate inflammatory biomarkers associated with improved motor performance in induced kOA-like changes, thus preventing the loss of chondrocytes.
local.identifier.orcidhttps://orcid.org/0000-0002-1696-6091
local.identifier.orcidhttps://orcid.org/ 0000-0003-0420-445X
local.identifier.orcidhttps://orcid.org/ 0000-0001-6358-4910
local.identifier.orcidhttp://orcid.org/0000-0001-8977-8131
local.identifier.orcidhttp://orcid.org/0000-0003-2719-4231
local.identifier.orcidhttp://orcid.org/0000-0001-8981-6724
local.identifier.orcidhttps://orcid.org/ 0000-0002-8658-3774
local.identifier.orcidhttps://orcid.org/ 0000-0002-4718-448X
local.identifier.orcidhttps://orcid.org/ 0000-0001-5366-3754
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fphys.2019.01168/full

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