Thermosensitive liposomes containing cisplatin functionalized by hyaluronic acid: preparation and physicochemical characterization

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dc.creatorIsabela Pereira Gomes
dc.creatorÂngelo Malachias de Souza
dc.creatorAna Luiza Chaves Maia
dc.creatorEduardo Burgarelli Lages
dc.creatorFelipe Alves Ferreira
dc.creatorRicardo José Alves
dc.creatorCristiane dos Santos Giuberti
dc.creatorAndré Luís Branco de Barros
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-06-05T15:22:07Z
dc.date.accessioned2025-09-09T00:44:06Z
dc.date.available2023-06-05T15:22:07Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s11051-021-05352-9
dc.identifier.issn1572-896X
dc.identifier.urihttps://hdl.handle.net/1843/54503
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Nanoparticle Research
dc.rightsAcesso Restrito
dc.subjectLipossomos
dc.subject.otherThermosensitive liposomes
dc.subject.otherHyaluronic acid
dc.subject.otherLipid bilayer
dc.titleThermosensitive liposomes containing cisplatin functionalized by hyaluronic acid: preparation and physicochemical characterization
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue2
local.citation.spage1
local.citation.volume24
local.description.resumoThis study aimed to develop a thermosensitive liposomal formulation (TSL) functionalized with hyaluronic acid (HA), to encapsulate a hydrophilic drug, the cisplatin (CDDP). The physicochemical and thermal characteristics of this new formulation were studied by dynamic light scattering (DLS), microcalorimetry, and small-angle X-ray scattering (SAXS) techniques. Our results showed mean diameter and PDI data characteristics of homogeneous formulations, indicating the absence of aggregation of vesicles after functionalization with HA. The efficiency of coating in the liposome surface was attributed to zeta potential values close to neutrality. DLS data showed a significant reduction in the average diameter and Kcps of the formulations evaluated at 40 °C. It was also observed that the HA-coating did not alter the Tm of the formulations. The SAXS profile of all formulations was characteristic of a lamellar organization regardless of temperature evaluated and showed dilation of the bilayer, caused by local misorientation in the structure of the lipids, confirming the conformational alteration due to warming. Therefore, the in vitro release profile showed that possible drug adsorption in the phospholipid bilayer may be generating the diffusion rate of CDDP before reaching Tm (42 °C), for TSL-CDDP and TSL-CDDP-SA-HA. For TSL-CDDP-HA, the presence of the polymer may be modulating this diffusion, generating a more controlled and slow release profile.
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0002-2458-6021
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8731
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11051-021-05352-9

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