Ovarian sex hormones modulate compulsive, affective and cognitive functions in a non-induced mouse model of obsessive-compulsive disorder

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dc.creatorSwarup Mitra
dc.creatorCristiane P. Bastos
dc.creatorKatherine Bates
dc.creatorGrace Schenatto Pereira Moraes
dc.creatorAbel Bult-Ito
dc.date.accessioned2023-07-14T20:31:56Z
dc.date.accessioned2025-09-08T23:47:44Z
dc.date.available2023-07-14T20:31:56Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.3389/fnbeh.2016.00215
dc.identifier.issn1662-5153
dc.identifier.urihttps://hdl.handle.net/1843/56296
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Behavioral Neuroscience
dc.rightsAcesso Aberto
dc.subjectComportamento compulsivo
dc.subjectMenopausa
dc.subjectProgesterona
dc.subject.otherCompulsive-like behavior
dc.subject.otherOvariectomy
dc.subject.otherStrain differences
dc.subject.otherSurgical menopause
dc.subject.other17 β-estradiol
dc.subject.otherProgesterone
dc.titleOvarian sex hormones modulate compulsive, affective and cognitive functions in a non-induced mouse model of obsessive-compulsive disorder
dc.typeArtigo de periódico
local.citation.epage220
local.citation.spage215.
local.citation.volume10
local.description.resumoThere is currently a lack of understanding of how surgical menopause can influence obsessions, compulsions and associated affective and cognitive functions in female obsessive-compulsive disorder (OCD) patients. Early menopause in women due to surgical removal of ovaries not only causes dramatic hormonal changes, but also may induce affective and cognitive disorders. Here, we tested if surgical removal of ovaries (ovariectomy, OVX), which mimics surgical menopause in humans, would result in exacerbation of compulsive, affective and cognitive behaviors in mice strains that exhibit a spontaneous compulsive-like phenotype. Female mice from compulsive-like BIG, non-compulsive SMALL and randomly-bred Control strains were subjected to OVX or sham-surgery. After 7 days animals were tested for nest building and marble burying to measure compulsive-like behavior. The elevated plus maze and open field tests measured anxiety-like behaviors, while memory was assessed by the novel object recognition. Acute OVX resulted in exacerbation of compulsive-like and anxiety-like behaviors in compulsive-like BIG mice. No significant effects of OVX were observed for the non-compulsive SMALL and Control strains. Object recognition memory was impaired in compulsive-like BIG female mice compared to the Control mice, without an effect of OVX on the BIG mice. We also tested whether 17 β-estradiol (E2) or progesterone (P4) could reverse the effects of OVX. E2, but not P4, attenuated the compulsive-like behaviors in compulsive-like BIG OVX female mice. The actions of the sex steroids on anxiety-like behaviors in OVX females were strain and behavioral test dependent. Altogether, our results indicate that already existing compulsions can be worsened during acute ovarian deprivation concomitant with exacerbation of affective behaviors and responses to hormonal intervention in OVX female mice can be influenced by genetic background.
local.identifier.orcidhttps://orcid.org/0000-0001-6762-3817
local.identifier.orcidhttps://orcid.org/0000-0003-3016-9395
local.identifier.orcidhttps://orcid.org/0000-0002-6524-4036
local.identifier.orcidhttps://orcid.org/0000-0002-4681-7054
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fnbeh.2016.00215/full

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