Experience of the first Brazilian fecal microbiota transplantation center in treating recurrent Clostridioides difficile infection

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dc.creatorDaniel Albuquerque Terra
dc.creatorEduardo Garcia Vilela
dc.creatorRodrigo Otávio Silveira Silva
dc.creatorLlaiane Alves Leão
dc.creatorKarine Sampaio Lima
dc.creatorEdward j. Kuijper
dc.creatorRaissa Iglesias Fernandes Ângelo Passos
dc.creatorLuiz Gonzaga Vaz Coelho
dc.date.accessioned2023-12-06T19:28:08Z
dc.date.accessioned2025-09-09T00:16:46Z
dc.date.available2023-12-06T19:28:08Z
dc.date.issued2022-12-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi/10.26355/mhd_202212_806
dc.identifier.issn2704-8845
dc.identifier.urihttps://hdl.handle.net/1843/61802
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMicrobiota in Health and Disease
dc.rightsAcesso Aberto
dc.subjectTransplante de Microbiota Fecal
dc.subjectInfecções por Clostridium
dc.subjectRibotipagem
dc.subject.otherFecal microbiota transplantation
dc.subject.otherClostridioides difficile infection
dc.subject.otherStool bank
dc.subject.otherRibotypes
dc.titleExperience of the first Brazilian fecal microbiota transplantation center in treating recurrent Clostridioides difficile infection
dc.typeArtigo de periódico
local.citation.epage12
local.citation.issue4
local.citation.spagee806
local.citation.volume4
local.description.resumoIntroduction: Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea related to the use of antimicrobials worldwide. Treatment of recurrent CDI is challenging in countries where fecal microbiota transplantation (FMT) is not widely available. Furthermore, data on the effectiveness and safety of FMT in emerging countries are scarce. Thus, this study aimed to describe the initial experience of the first fecal microbiota transplantation center in Brazil for the treatment of recurrent CDI using frozen samples. Materials and Methods: FMT was performed via colonoscopy using frozen samples from a stool bank. Donors were screened according to international guidelines and national regulatory resolutions. CDI diagnosis was confirmed in all patients. FMT success was defined as cessation of diarrhea within eight weeks. C. difficile isolates were subjected to ribotyping and antimicrobial susceptibility testing. Results: Over two years, ten patients with recurrent CDI underwent FMT. The median age was 68 years (range: 23-87 years), 70% were women, 60% had severe infection. Furthermore, a median of 3 previous CDI episodes (range: 1-4) was observed. The primary resolution with a single FMT was 80%, while the overall resolution after the second FMT was 90%. Failure of treatment was not related to CDI severity (p = 0.273), bowel preparation (p = 0.345), comorbidities (p = 0.809), or number of previous episodes (p = 0.457). No serious adverse events were described during the follow-up of 26.6 months (range: 26.6-38.2 months). Mild adverse events occurred in 54.5% of the cases, which was mainly abdominal discomfort on the first day after the procedure. In addition, toxigenic C. difficile isolates belonged to ribotypes 106, 014/020, 131, 076, and 037. All the isolates were susceptible to metronidazole and vancomycin. Conclusions: FMT is a safe and effective treatment for recurrent CDI in this cohort of Brazilian patients. The implementation of a stool bank allowed for the proper application of all the requirements needed to perform FMT in the country.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://www.microbiotajournal.com/article/806

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