The utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical staging

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dc.creatorLuiz Claudio Santos Thuler
dc.creatorBárbara Reis Wariss
dc.creatorAngélica Nogueira Rodrigues
dc.creatorAndreia Cristina de Melo
dc.creatorAnke Bergmann
dc.date.accessioned2023-08-14T21:09:12Z
dc.date.accessioned2025-09-09T00:51:12Z
dc.date.available2023-08-14T21:09:12Z
dc.date.issued2021-07-21
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ejogrb.2021.07.034
dc.identifier.issn0301-2115
dc.identifier.urihttps://hdl.handle.net/1843/57816
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.rightsAcesso Restrito
dc.subjectNeoplasias do Colo do Útero
dc.subjectSobrevivência
dc.subject.otherInflammatory markers
dc.subject.otherCervical Cancer
dc.subject.otherSurvival
dc.subject.otherClinical staging
dc.titleThe utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical staging
dc.typeArtigo de periódico
local.citation.epage288
local.citation.spage281
local.citation.volume264
local.description.resumoObjective: Inflammation plays a crucial role in the initiation and progression of many cancers. This study aimed to investigate the utility of pretreatmentneutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), derived neutrophil–lymphocyte ratio (dNLR), and a combination of PLR and NLR in predicting the risk of death according to clinical staging in cervical cancer (CC) patients.Methods: A cohort study of women with CC, diagnosed and treated at a single cancer referral center in Brazil, from 2006 to 2009. A multivariate Cox regression analysis and ROC curve analysis accessed the predictive value of inflammatory response biomarkers in overall survival (OS). The median values of the biomarkers were used as cut-off points.Results: A total of 1,266 patients were included in the study, 76.0% with locally advanced disease. After adjusting for clinical variables, NLR > 2.57, PLR 146.70, dNLR 1.778 and PLR + NLR in combination had equivalent performance in predicting worse OS, but only among patients with locally advanced disease (adjusted Hazard Ratio [aHR] = 1.453, 95% Confidence Interval [CI] = 1.227–1.722; p < 0.001; aHR = 1.429; 95% CI = 1.209–1.688; p < 0.001; aHR = 1.486, 95% CI = 1.257–1.756, p < 0.001, aHR = 1.731; 95% CI = 1.411–2.123; p < 0.001, respectively).Conclusion: In conclusion, PLR, NLR, dNLR and PLR + NLR in combination presented equivalent perfor mance in predicting OS in locally advanced CC patients. They are simple and readily available from rou tine blood tests, not entailing additional costs. PLR, NLR, dNLR and PLR + NLR in combination are strong prognostic biomarkers candidates in locally advanced CC and should be further explored in prospective trials.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.ejog.org/article/S0301-2115(21)00377-8/fulltext

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