Bone strength is reduced in a neonatal androgenized rat model

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dc.creatorLady Katerine Serrano Mujica
dc.creatorAntônio Carlos Shimano
dc.creatorAlfredo Quites Antoniazzi
dc.creatorMelissa Orlandin Premaor
dc.creatorFabio Vasconcellos Comim
dc.creatorCarolina dos Santos Amaral
dc.creatorFernanda Soldatelli Valente
dc.creatorLigia Gomes Miyazato
dc.creatorSoraia Macari
dc.creatorTarcília Aparecida da Silva
dc.creatorBreno Rocha Barrioni
dc.creatorBruna Leonel Carlos
dc.creatorGuilherme Jafroni Alves Silva
dc.date.accessioned2025-05-19T21:49:33Z
dc.date.accessioned2025-09-08T23:11:44Z
dc.date.available2025-05-19T21:49:33Z
dc.date.issued2023-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bonr.2023.101710
dc.identifier.issn2352-1872
dc.identifier.urihttps://hdl.handle.net/1843/82349
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBone reports
dc.rightsAcesso Aberto
dc.subjectBone and bones
dc.subjectPolycystic ovary syndrome
dc.subjectMechanical tests
dc.subjectBone resorption
dc.subjectFemur
dc.subjectCollagen type I
dc.subjectOvariectomy
dc.subject.otherPolycystic ovary syndrome
dc.subject.otherBone
dc.subject.otherAnimal models of PCOS
dc.subject.othermicroCT
dc.subject.otherMechanical test
dc.titleBone strength is reduced in a neonatal androgenized rat model
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume19
local.description.resumoBackground: Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, and we aimed to use it to investigate the impact of androgens on microarchitecture (by micro-CT), bone mechanical strength, bone formation and resorption markers in rats with intact ovaries (SHAM) who underwent oophorectomy. Methods: Wistar rats (Rattus norvegicus albinus) were employed for the experiments in this study. The protocol of androgenization consisted of the application of 1.25 mg s.c. testosterone propionate beteween days 2–5 of life, while the controls received the same amount of corn oil s.c. as previously established. Androgenized SHAM rats exhibited chronic anovulation identified by vaginal cytology and a reduction in the proportion of corpus luteum in the ovary in comparison to control SHAM rats. The realization of the ovariectomy or SHAM procedure occurred on Day 100 of life. All groups (n = 8) were followed-up for 180 days to address the study endpoints. Results: Micro-CT from androgenized female rats (SHAM) showed a divergence between the trabecular and cortical bone profiles. Compared to SHAM controls, these rats had an increase in trabecular bone mass with a diminution in bone resorption C-terminal telopeptide of type 1 collagen (CTX) (p < 0.05), a concomitant decrease in cortical area and thickness in the femur, and a reduction in the strength of the femur on the mechanical test (p < 0.01). Conclusions: Our results suggest that a reduction in the cortical thickness and cortical area observed in PCOS model rats was associated with a reduced strength of the femur, despite increased trabecular formation. Ovariectomy in the androgenized OVX group limited the progression rate of cortical bone loss, resulting in bone resistance and cortical thickness comparable to those observed in the control OVX group.
local.identifier.orcidhttps://orcid.org/0000-0001-8009-1480
local.identifier.orcidhttps://orcid.org/0000-0002-3119-2362
local.identifier.orcidhttps://orcid.org/0000-0003-4866-5944
local.identifier.orcidhttps://orcid.org/0000-0002-0770-9202
local.identifier.orcidhttps://orcid.org/0000-0002-2726-233X
local.identifier.orcidhttps://orcid.org/0000-0002-5932-0522
local.identifier.orcidhttps://orcid.org/0000-0001-9317-4605
local.identifier.orcidhttps://orcid.org/0000-0001-8556-5083
local.identifier.orcidhttps://orcid.org/0000-0001-7643-6589
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-8681-6451
local.identifier.orcidhttps://orcid.org/0000-0002-6726-4217
local.identifier.orcidhttps://orcid.org/0000-0001-7621-1726
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S235218722300058X#ks0005

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