Unveiling the potential of angiotensin-converting enzyme as a therapeutic target in head and neck squamous carcinoma

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dc.creatorEmisael Stênio Batista Gomes
dc.creatorMarcela Gonçalves de Souza
dc.creatorRogério Gonçalves da Rocha
dc.creatorLincoln Valério Andrade Rodrigues
dc.creatorMaria Isabela Campos Ruas
dc.creatorOsvaldo Sena Guimarães
dc.creatorLucyana Conceição Farias
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2025-08-05T17:42:25Z
dc.date.accessioned2025-09-08T23:53:07Z
dc.date.available2025-08-05T17:42:25Z
dc.date.issued2024-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.genrep.2023.101858
dc.identifier.issn2452-0144
dc.identifier.urihttps://hdl.handle.net/1843/84058
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectCarcinoma de células escamosas
dc.subjectEnzima conversora da angiotensina - Inibidores
dc.titleUnveiling the potential of angiotensin-converting enzyme as a therapeutic target in head and neck squamous carcinoma
dc.typeArtigo de periódico
local.citation.spage101858
local.citation.volume34
local.description.resumoThis study investigated the effects of ACE inhibition on Head and Neck Squamous Cell Carcinoma (HNSCC), tumor progression, and the relation of ACE2, AGTR1, ACE, and MAS1 expression with HNSCC patient` survival. ACE inhibitor (Captopril) treatment was applied into Swiss male mice. ACE2, AGTR1, ACE, and MAS1 expression levels were analyzed in HNSCC tumor tissues from The Cancer Genome Atlas (TCGA) database. ACE inhibition reduced cell viability, proliferation, migration, and invasion, increased ROS levels, and induced apoptosis in SCC9 cells. Neoplastic angiogenesis was suppressed by ACE inhibition in the CAM assay. ACE inhibition also reduced the incidence of severe dysplasia/carcinoma in the histological analysis. TCGA data revealed that lower ACE2 levels were associated with poorer survival outcomes, while increased AGTR1 expression correlated with a higher risk of death in HPV-negative patients. ACE upregulation and higher MAS1 expression were observed in HNSCC tumor tissues. ACE inhibition demonstrated anti-cancer effects in HNSCC cells and suppressed neoplastic angiogenesis. It also reduced histological aggressiveness and showed potential predictive value for ACE2 and AGTR1 expression levels in HNSCC. These findings suggest the therapeutic potential of ACE inhibitors in HNSCC treatment, requiring further investigation and validation in clinical settings.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2452014423001206

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