Image quality evaluation for two different positron emitters in a preclinical pet scanner

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dc.creatorRodrigo Modesto Gadelha Gontijo
dc.creatorAndréa Vidal Ferreira
dc.creatorGuilherme Cavalcante de Albuquerque Souza
dc.creatorJuliana Batista da Silva
dc.creatorMarcelo Mamede
dc.date.accessioned2023-08-02T21:02:48Z
dc.date.accessioned2025-09-09T00:20:23Z
dc.date.available2023-08-02T21:02:48Z
dc.date.issued2020-09-19
dc.format.mimetypepdf
dc.identifier.doi10.15392/bjrs.v8i3.1299
dc.identifier.issn23190612
dc.identifier.urihttps://hdl.handle.net/1843/57387
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Radiation Sciences
dc.rightsAcesso Aberto
dc.subjectTomografia por Emissão de Pósitrons
dc.subjectDiagnóstico por Imagem
dc.subject.otherImage Quality
dc.subject.otherPreclinical PET scanner
dc.titleImage quality evaluation for two different positron emitters in a preclinical pet scanner
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue3
local.citation.spage01
local.citation.volume8
local.description.resumoPositron emission tomography (PET) is widely used in preclinical trials, generating molecular images applied to biochemical, metabolic and functional investigation of organs and tissues. The positron emitters 11C and 18F are relevant for different diseases studies. However, they have different positron energies, ranges, and branching ratio. This could result in a distinct quality between the acquired PET images. Thus, the aim of this study was to evaluate differences in the image quality performance of the PET scanner (LabPET 4, GE) at Molecular Imaging Laboratory (LIM/CDTN) depending on the use of18F or 11C. The study followed the guidelines of the NEMA NU 4-2008 standards and the recommended specific phantom was used in experimental procedures. The NEMA image-quality (IQ) phantom consists of 3 different regions to analyze distinct characteristics: uniformity, recovery coefficients (RCs) and spill-over rations (SOR) in air and water. The IQ phantom was filled with two different aqueous solutions (18F-FDG and 11C-PK11195), both activities calibrated at the beginning of acquisition (3.7MBq). The IQ phantom was placed in the center of the field-of-view (FOV) and measured with the LIM/CDTN typical whole body imaging protocol. The images were reconstructed following the LIM/CDTN standard protocol: MLEM-3D algorithm, 20 iterations, no high-resolution mode, no attenuation or scatter corrections, no post-filtering. PMOD® software was used to perform images post-processing. Uniformity test revealed that 11C PET image roughness is about twice 18F PET image roughness. SOR tests indicated around 15% more counts in cold volumesin 11C PET image than in 18F PET image. The RCs for 11C were systematically lower and with higher percentage standard deviations than those for 18F. This study demonstrated and quantified the best performance of PET images with 18F when compared to 11C. This fact must be taken into account in laboratorial practice, especially when quantitative analyzes are performed.
local.identifier.orcid0000-0001-6479-3087
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.initialsUFMG
local.url.externahttps://www.bjrs.org.br/revista/index.php/REVISTA/article/view/1299

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