Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

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dc.creatorPedro A. C. Costa
dc.creatorMauro C. X. Pinto
dc.creatorJaime H. Amorim
dc.creatorVasco Ariston de Carvalho Azevedo
dc.creatorRodrigo R. Resende
dc.creatorRemo C. Russo
dc.creatorThiago M. Cunha
dc.creatorPedro A. F. Galante
dc.creatorAkiva Mintz
dc.creatorAlexander Birbrair
dc.creatorWalison N. Silva
dc.creatorPedro H. D. M. Prazeres
dc.creatorCaroline C. Picoli
dc.creatorGabriela D. A. Guardia
dc.creatorAlinne C. Costa
dc.creatorMariana A. Oliveira
dc.creatorPedro P. G. Guimarães
dc.creatorRicardo Gonçalves
dc.date.accessioned2023-09-14T19:11:07Z
dc.date.accessioned2025-09-08T23:16:48Z
dc.date.available2023-09-14T19:11:07Z
dc.date.issued2021-11-16
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s40478-021-01273-9
dc.identifier.issn2051-5960
dc.identifier.urihttps://hdl.handle.net/1843/58677
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Neuropathologica Communications
dc.rightsAcesso Aberto
dc.subjectCélulas Receptoras Sensoriais
dc.subjectMicroambiente Tumoral
dc.subjectMelanoma
dc.subject.otherSensory neurons
dc.subject.otherTumor microenvironment
dc.subject.otherMelanoma
dc.subject.otherNeuronal activity
dc.subject.otherChemogenetics
dc.titleChemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
dc.typeArtigo de periódico
local.citation.epage41
local.citation.issue183
local.citation.spage1010010
local.citation.volume9
local.description.resumoSensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Designer Drug (DREADD) technology to inhibit or activate sensory neurons’ firing within the melanoma tumor. Melanoma growth and angiogenesis were accelerated following inhibition of sensory neurons’ activity and were reduced following overstimulation of these neurons. Sensory neuron-specific overactivation also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of melanoma biopsies revealed that increased expression of sensory neurons-related genes within melanoma was associated with improved survival. These findings suggest that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.
local.identifier.orcidhttp://orcid.org/0000-0002-1715-3834
local.identifier.orcidhttp://orcid.org/0000-0003-1015-2561
local.identifier.orcidhttps://orcid.org/0000-0002-1127-4483
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01273-9#rightslink

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