Lung function six months after severe covid-19: does time, in fact, heal all wounds?

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dc.creatorDaniel Cruz Bretas
dc.creatorCarolina Coimbra Marinho
dc.creatorArnaldo Santos Leite
dc.creatorEliane Viana Mancuzo
dc.creatorTarciane Aline Prata
dc.creatorBruno Horta Andrade
dc.creatorJacqueline Das Graças Ferreira Oliveira
dc.creatorAline Priscila Batista
dc.creatorGeorge Luiz Lins Machado Coelho
dc.creatorValéria Maria Augusto
dc.date.accessioned2023-10-26T19:39:58Z
dc.date.accessioned2025-09-09T00:34:32Z
dc.date.available2023-10-26T19:39:58Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bjid.2022.102352
dc.identifier.issn14138670
dc.identifier.urihttps://hdl.handle.net/1843/60102
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Brazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectRespiratory Function Tests
dc.subjectFollow-Up Studies
dc.subjectPost-Acute COVID-19 Syndrome
dc.subject.otherCOVID-19
dc.subject.otherLung Function
dc.subject.otherFollow-Up
dc.subject.otherPost-COVID condition
dc.titleLung function six months after severe covid-19: does time, in fact, heal all wounds?
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume26
local.description.resumoBackground: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease.Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon mon oxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis.Results: 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed signifi cant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC,FEV1, total lung capacity, and 6MW distance measures. The improvement in the propor tions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m;p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001).Conclusion: Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital dis charge. The difference was more evident in those requiring ICU admission.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externadoi:10.1016/j.bjid.2022.102352

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