The use of occlusive dressings: influence on excisional wound healing in animal model

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dc.creatorMariana Raquel Soares Guillen
dc.creatorEline Lima Borges
dc.creatorGilmara Lopes Amorim
dc.creatorPuebla Cassini Vieira
dc.creatorAntonio Carlos Martins Guedes
dc.creatorLucíola da Silva Barcelos
dc.date.accessioned2024-07-12T20:02:56Z
dc.date.accessioned2025-09-08T23:35:10Z
dc.date.available2024-07-12T20:02:56Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doi10.1590/acb371206
dc.identifier.issn16782674
dc.identifier.urihttps://hdl.handle.net/1843/70472
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectWounds and Injuries
dc.subjectOcclusive Dressings
dc.subjectDescritor em espanhol:
dc.subjectInflammation
dc.subject.otherWounds and Injuries
dc.subject.otherWound Healing
dc.subject.otherOcclusive Dressings
dc.subject.otherInflammation
dc.titleThe use of occlusive dressings: influence on excisional wound healing in animal model
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue12
local.citation.spage1
local.citation.volume37
local.description.resumoPurpose: To analyze the in昀氀uence of occlusive dressing on the healing of excisional skin wounds in mice. Methods: Pre-clinical, comparative, and translational study. Mice were divided into three experimental groups: wounds occluded with hydrocolloid (HD) dressings, transparent polyurethane 昀椀lm (TF) dressings, and without occlusion (WO), monitored at three, six and 14 days, with eight animals each. Closure rate, in昀椀ltration of neutrophils and macrophages, measurement of tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) and, histologically, angiogenesis were evaluated. Results: Wound closure was accelerated in the occlusive groups. There was a decrease in TNF-α levels in the HD group when compared to the WO and TF groups. Neutrophils accumulation decreased in the HD group. Increased dosages of macrophages were evidenced in the HD group, compared to the WO and TF groups. Levels of VEGF were increased in the TF and HD groups. Conclusion: It is suggested that the occlusion of wounds modulates the in昀氀ammatory response.
local.identifier.orcidhttps://orcid.org/0000-0003-1220-6041
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM BÁSICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/acb371206

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