Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice

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dc.creatorIan de Meira Chaves
dc.creatorDaniele da Glória de Souza
dc.creatorMila Fernandes Moreira Madeira
dc.creatorMarina Campos Zicker
dc.creatorAlice de Oliveira Laranjeira
dc.creatorAna Letícia Malheiros Silveira
dc.creatorDaniele Cristina de Aguiar
dc.creatorBreno Rocha Barrioni
dc.creatorAdaliene Versiani de Matos Ferreira
dc.creatorMauro Martins Teixeira
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-05-13T19:02:25Z
dc.date.accessioned2025-09-08T23:00:49Z
dc.date.available2025-05-13T19:02:25Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2022-0238
dc.identifier.issn1678-7765
dc.identifier.urihttps://hdl.handle.net/1843/82251
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Oral Science
dc.rightsAcesso Aberto
dc.subjectPeriodontal diseases
dc.subjectObesity
dc.subjectAlveolar bone loss
dc.subjectMice
dc.subjectNeutrophils
dc.subjectChlorhexidine
dc.subjectPeriodontics
dc.subject.otherPeriodontal diseases
dc.subject.otherObesity
dc.subject.otherAlveolar bone loss
dc.subject.otherMice
dc.subject.otherOral microbiota
dc.titleDysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
dc.typeArtigo de periódico
local.citation.spagee20220238
local.citation.volume30
local.description.resumoPeriodontal diseases (PD) are inflammatory conditions that affect the teeth supporting tissues. Increased body fat tissues may contribute to activation of the systemic inflammatory response, leading to comorbidities. Some studies have shown that individuals with obesity present higher incidence of PD than eutrophics. Objective: To investigate the impact of obesity on periodontal tissues and oral microbiota in mice. Methodology: Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, a DNA-DNA hybridization technique was employed to evaluate the microbiota composition and topical application of chlorhexidine (CHX), an antiseptic, was used to investigate the impact of the oral microbiota on the alveolar bone regarding obesity. Results: Increased adipose tissue may induce alveolar bone loss, neutrophil recruitment, and changes in the oral biofilm, similar to that observed in an experimental model of PD. Topical application of CHX impaired bone changes. Conclusion: Obesity may induce changes in the oral microbiota and neutrophil recruitment, which are associated with alveolar bone loss.
local.identifier.orcidhttps://orcid.org/0000-0002-7478-5934
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0003-3380-1245
local.identifier.orcidhttps://orcid.org/0009-0005-6800-5144
local.identifier.orcidhttps://orcid.org/0000-0001-7635-8656
local.identifier.orcidhttps://orcid.org/0000-0002-8681-6451
local.identifier.orcidhttps://orcid.org/0000-0003-2256-8652
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jaos/a/ZhpyCrSZCcCjm9LL4jfZmsm/?lang=en

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