Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy

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dc.creatorMaxine Robert
dc.creatorJennifer Gutterman
dc.creatorKaren Chin
dc.creatorMarina de Brito Brandao
dc.creatorAndrew M. Gordon
dc.creatorKathleen Friel
dc.date.accessioned2024-03-04T22:27:25Z
dc.date.accessioned2025-09-08T23:38:52Z
dc.date.available2024-03-04T22:27:25Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1177%2F15459683211011220
dc.identifier.issn1545-9683
dc.identifier.urihttps://hdl.handle.net/1843/65214
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNeurorehabilitation and Neural Repair
dc.rightsAcesso Aberto
dc.subjectHemiplegia
dc.subjectExtremidades
dc.subjectParalisia Cerebral
dc.subject.otherHemiplegia
dc.subject.otherBrain damage
dc.subject.otherInterventions
dc.subject.otherDiffusion MRI
dc.subject.otherInterhemispheric connections
dc.titleCorpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy
dc.typeArtigo de periódico
local.citation.epage544
local.citation.issue6
local.citation.spage534
local.citation.volume35
local.description.resumoBackground The corpus callosum (CC) plays an important role in upper extremity (UE) function. The impact on UE function in children with unilateral spastic cerebral palsy (USCP) and improvements following intensive interventions remain unknown. Objectives To examine the (1) relationship between UE function and CC integrity and (2) relationship between CC integrity and changes in UE function following intensive interventions. Methods We retrospectively analyzed clinical and neuroimaging data from a sample of convenience of 44 participants (age 9.40 ± 3.10 years) from 2 larger trials. Participants received 90 hours of Hand-Arm Bimanual Intensive Therapy (HABIT) or Constraint-Induced Movement Therapy (CIMT). Unimanual dexterity (Jebsen-Taylor Test of Hand Function [JTTHF]) and bimanual performance (Assisting Hand Assessment [AHA]) were assessed preintervention and postintervention. CC tractography was reconstructed with diffusion tensor imaging (DTI) and segmented into 3 regions (genu, midbody, splenium). Pearson correlations and regression were used to assess the relationship between outcomes and DTI parameters (ie, fractional anisotropy [FA], number of streamlines, and mean, radial, and axial diffusivity). Results Both groups improved in bimanual performance (P < .01). The CIMT group improved in unimanual dexterity (P < .01). Baseline unimanual dexterity and bimanual performance correlated with FA and number of streamlines for most CC regions (P < .05). Following CIMT, pre-post changes in JTTHF were negatively correlated with axial and radial diffusivity of the CC, and AHA with splenium and number of streamlines for the CC, midbody, and splenium (all P < .05). Following HABIT, midbody FA was positively correlated with pre-post AHA changes (r = 0.417; P = .042). Conclusions CC integrity is important for UE function in children with USCP.
local.identifier.orcidhttps://orcid.org/0000-0001-5192-0868
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL
local.publisher.departmentEEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONAL
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135240/

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