Radionuclide imaging in chagas cardiomyopathy

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dc.creatorMarcus Vinicius Simões
dc.creatorLeonardo Pippa Gadioli
dc.creatorLuciano Fonseca Lemos de Oliveira
dc.date.accessioned2022-05-02T18:48:20Z
dc.date.accessioned2025-09-09T00:48:51Z
dc.date.available2022-05-02T18:48:20Z
dc.date.issued2019-02
dc.identifier.doihttps://doi.org/10.1007/s12410-019-9482-8
dc.identifier.issn1941-9074
dc.identifier.urihttps://hdl.handle.net/1843/41298
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Cardiovascular Imaging Reports
dc.rightsAcesso Restrito
dc.subjectDoença de Chagas
dc.subjectCardiomiopatia chagásica
dc.subjectDiagnóstico por imagem
dc.subjectCintilografia
dc.subjectReperfusão miocárdica
dc.subjectMiocardite
dc.subject.otherChagas disease
dc.subject.otherCardiomyopathy
dc.subject.otherRadionuclide imaging
dc.subject.otherScintigraphy
dc.subject.otherMyocardial perfusion
dc.subject.otherMyocarditis
dc.titleRadionuclide imaging in chagas cardiomyopathy
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue2
local.citation.spage1
local.citation.volume12
local.description.resumoPurpose of Review: To review the contributions of radionuclide imaging to understanding the manifestations and pathophysiology of chronic Chagas cardiomyopathy (CCC). Recent Findings: Experimental studies using high-resolution SPECT myocardial perfusion imaging (MPI) show that myocardial perfusion derangement that corresponds to dysfunctional, viable myocardium is closely linked to inflammation and precedes LV regional systolic dysfunction. Clinical studies show that microvascular ischemia is strictly related to the areas of cardiac sympathetic denervation, assessed by 123I-MIBG imaging, which correlates with severe ventricular arrhythmia incidence. Initial case reports suggest that 18F-FDG-PET imaging is a promising, non-invasive detection method for myocardial inflammation. Summary: Available evidence indicates that microvascular ischemia participates in the mechanisms causing myocardial injury in CCC, with potential implication for monitoring subclinical disease progression. Moreover, MIBG imaging is a promising tool for risk stratification of sudden death. Preliminary clinical experience suggests a role for 18F-FDG-PET in detection of inflammation in CCC.
local.identifier.orcidhttps://orcid.org/ 0000-0001-6553-8387
local.identifier.orcidhttps://orcid.org/ 0000-0003-3455-2463
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12410-019-9482-8#author-information

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