Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

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dc.creatorJôice Dias Corrêa
dc.creatorTarcília Aparecida da Silva
dc.creatorDébora Cerqueira Calderaro
dc.creatorGilda Aparecida Ferreira
dc.creatorSantuza Maria Souza Mendonça
dc.creatorGabriel R. Fernandes
dc.creatorE. Xiao
dc.creatorAntônio Lúcio Teixeira
dc.creatorEugene J. Leys
dc.creatorDana T. Graves
dc.date.accessioned2023-07-20T20:58:35Z
dc.date.accessioned2025-09-08T23:13:25Z
dc.date.available2023-07-20T20:58:35Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s40168-017-0252-z
dc.identifier.issn20492618
dc.identifier.urihttps://hdl.handle.net/1843/56795
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMicrobiome
dc.rightsAcesso Aberto
dc.subjectLupus
dc.subjectPeriodontite
dc.subjectCitocinas
dc.subjectPlaca Dentária
dc.subjectSequenciamento de Nucleotídeos em Larga Escala
dc.subject.otherLupus
dc.subject.otherOral microbiota
dc.subject.otherPeriodontitis
dc.subject.otherCytokine
dc.subject.otherSubgingival dental plaque
dc.subject.otherIllumina sequencing
dc.titleSubgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue34
local.citation.spage1
local.citation.volume5
local.description.resumoBackground: Periodontitis results from the interaction between a subgingival biofilm and host immune response.Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity.Methods: We evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing.Results: SLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis. Conclusions: SLE is associated with differences in the composition of the microbiota, independently of periodontal status.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0252-z

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