Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism

Página do item simplificado
dc.creatorCláudia Ribeiro
dc.creatorMaria Goretti Moreira Guimarães Penido
dc.creatorMilena Maria Moreira Guimarães
dc.creatorMarcelo de Sousa Tavares
dc.creatorBruno Das Neves Souza
dc.creatorAnderson Ferreira Leite
dc.creatorLeonardo Martins Caldeira de Deus
dc.creatorLucas José de Campos Machado
dc.date.accessioned2023-07-24T19:54:10Z
dc.date.accessioned2025-09-08T23:47:48Z
dc.date.available2023-07-24T19:54:10Z
dc.date.issued2016-09-06
dc.format.mimetypepdf
dc.identifier.doi10.5527/wjn.v5.i5.437
dc.identifier.issn22206124
dc.identifier.urihttps://hdl.handle.net/1843/56912
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofWorld Journal of Nephrology
dc.rightsAcesso Aberto
dc.subjectHiperparatireoidismo Secundário
dc.subjectSinalização do Cálcio
dc.subjectFósforo
dc.subjectHormônio Paratireóideo
dc.subjectAlkaline phosphatase
dc.subjectFosfatase Alcalina
dc.subjectInsuficiência Renal Crônica
dc.subject.otherSecondary hyperparathyroidism
dc.subject.otherParathyroid ultrasonography
dc.subject.otherCalcium
dc.subject.otherPhosphorus
dc.subject.otherParathyroid Hormone
dc.subject.otherAlkaline phosphatase
dc.subject.otherChronic kidney disease
dc.subject.otherBone alkaline phosphatase
dc.titleParathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism
dc.typeArtigo de periódico
local.citation.epage447
local.citation.issue5
local.citation.spage437
local.citation.volume5
local.description.resumoTo evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS:This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics (etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory (calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ 2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Studentt-test was used to detect differences between the two groups regarding continuous variables.RESULTS: Fifty-three patients (66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product (P = 0.03 and P = 0.006, respectively). They also had lower mortality (32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events (27% vs 73%,P = 0.02). Calcium× phosphorus product above 55 mg2/dL2 [RR 1.48 (1.06,2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25 (1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality. CONCLUSION:The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.wjgnet.com/2220-6124/abstract/v5/i5/437.htm

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Parathyroid ultrasonography and bone metabolic profile of pdfa.pdf
Tamanho:
856.8 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG