Psychotria viridis: chemical constituents from leaves and biological properties

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dc.creatorDébora B. S. Soares
dc.creatorLucienir P. Duarte
dc.creatorAndré D. Cavalcanti
dc.creatorFernando C. Silva
dc.creatorAriadne D. Braga
dc.creatorMiriam T. P. Lopes
dc.creatorJacqueline Aparecida Takahashi
dc.creatorSidney A. Vieira-filho
dc.date.accessioned2023-10-09T23:21:04Z
dc.date.accessioned2025-09-08T22:55:56Z
dc.date.available2023-10-09T23:21:04Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720160411
dc.identifier.issn0001-3765
dc.identifier.urihttps://hdl.handle.net/1843/59346
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAcademia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectTumores
dc.subjectFitoquímicos
dc.subject.otherPsychotria viridis
dc.subject.otherRubiaceae
dc.subject.otherN,N-dimethyltryptamine
dc.subject.otherB16F10
dc.subject.other4T1 tumor cells
dc.titlePsychotria viridis: chemical constituents from leaves and biological properties
dc.typeArtigo de periódico
local.citation.epage938
local.citation.issue2
local.citation.spage927
local.citation.volume89
local.description.resumoThe phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.publisher.countryBrasil
local.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO
local.publisher.departmentFAE - FACULDADE DE EDUCAÇÃO
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/yj9LRqGsz4RZRTh9rVNpy9j/?lang=en

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