Modulation of streptococcus mutans virulence by dental adhesives containing anti-caries agents

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dc.creatorCarolina Bosso André
dc.creatorPedro Luiz Rosalen
dc.creatorLívia Câmara de Carvalho Galvão
dc.creatorBruna Marin Fronza
dc.creatorGlaucia Maria Bovi Ambrosano
dc.creatorJack Liborio Ferracane
dc.creatorMarcelo Giannini
dc.date.accessioned2022-08-29T17:37:10Z
dc.date.accessioned2025-09-09T01:01:11Z
dc.date.available2022-08-29T17:37:10Z
dc.date.issued2017-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.dental.2017.07.006
dc.identifier.issn01095641
dc.identifier.urihttps://hdl.handle.net/1843/44672
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDental Materials
dc.rightsAcesso Restrito
dc.subjectApigenin
dc.subjectDental cements
dc.subjectDental caries
dc.subjectStreptococcus mutans
dc.subject.otherApigenin
dc.subject.otherBacterial virulence
dc.subject.otherCaries
dc.subject.otherTt-farnesol
dc.subject.otherDental adhesives
dc.titleModulation of streptococcus mutans virulence by dental adhesives containing anti-caries agents
dc.typeArtigo de periódico
local.citation.epage1092
local.citation.issue10
local.citation.spage1084
local.citation.volume33
local.description.resumoObjectives: The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin. Methods: Apigenin (1mM) and tt-Farnesol (5mM) were added separately and in combination to a self-etch adhesive (CS3 - Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT - OptiBond S). Biofilm of S. mutans was grown on adhesive-coated hydroxyapatite disks for 115h and bacterial viability, dry-weight, alkali soluble, water soluble, intracellular polysaccharides and protein were quantified. Bond strength and dentin-adhesive interface were performed to analyze the effects of the incorporation on the physical properties and to identify changes in hybrid layer morphology. Results: Addition of Apigenin and Apigenin+tt-Farnesol to CS3, and Apigenin or tt-Farnesol to OPT reduced the dry-weight of S. mutans biofilm. Insoluble polysaccharide decreased with the addition of Apigenin to CS3 and tt-Farnesol to OPT. Intracellular polysaccharide decreased with addition of Apigenin and Apigenin+tt-Farnesol to CS3. No changes in dentin bond strength, resin-dentin interfacial morphology, total amount of protein and soluble polysaccharide were observed with the additions. Significance: Biofilms that are less cariogenic around dental restorations could decrease secondary caries formation; in addition, the reduction of virulence of S. mutans without necessarily killing the microorganism is more unlikely to induce antimicrobial resistance.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0109564117300556?via%3Dihub

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