Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil

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dc.creatorAna Valesca Fernandes Gilsonsilva
dc.creatorAdriano Neves Coelho
dc.creatorJúlia Maria Saraiva Duarte
dc.creatorAugusto Viana da Rocha
dc.creatorLuiz Gonzaga Paula de Almeida
dc.creatorJoão Locke Ferreira de Araújo
dc.creatorHilton Soares de Oliveira
dc.creatorNova Jersey Cláudio de Oliveira
dc.creatorCamila Zolini
dc.creatorJôsy Hubner de Sousa
dc.creatorElizângela Gonçalves de Souza
dc.creatorDiego Menezes
dc.creatorRafael Marques de Souza
dc.creatorLuciana de Lima Ferreira
dc.creatorAlexandra Lehmkuhl Gerber
dc.creatorAna Paula de Campos Guimarães
dc.creatorPaulo Henrique Silva Maia
dc.creatorFernanda Martins Marim
dc.creatorLucyene Miguita
dc.creatorCristiane Campos Monteiro
dc.creatorTuffi Saliba Neto
dc.creatorFabrícia Soares Freire Pugêdo
dc.creatorFilipe Romero Rebello Moreira
dc.creatorDaniel Costa Queiroz
dc.creatorDamares Nigia Alborguetti Cuzzuol Queiroz
dc.creatorLuciana Cunha Resende-Moreira
dc.creatorFranciele Martins Santos
dc.creatorErika Fernanda Carlos Souza
dc.creatorCarolina Moreira Voloch
dc.creatorAna Tereza Vasconcelos
dc.creatorRenato Santana de Aguiar
dc.creatorRenan Pedra de Souza
dc.creatorOctávio Alcântara Torres
dc.creatorPaula Luize Camargos Fonseca
dc.creatorRennan Garcias Moreira
dc.creatorHugo José Alves
dc.creatorVivian Ribeiro Alves
dc.creatorTânia Maria de Resende Amaral
dc.date.accessioned2023-10-31T21:33:38Z
dc.date.accessioned2025-09-08T23:06:39Z
dc.date.available2023-10-31T21:33:38Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.799713
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/1843/60394
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Microbiology
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectGenomas
dc.subjectPandemia
dc.subject.otherCOVID-19
dc.subject.otherSARS-CoV-2
dc.subject.otherGenomas
dc.subject.otherPandemia
dc.titleSeroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage799713
local.citation.volume13
local.description.resumoThe COVID-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial pandemic stages in Betim City, Brazil. We collected 3239 subjects in a population-based age-, sex- and neighborhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling the same geographical area. In the first survey, overall prevalence (participants positive in serological or molecular tests) reached 0.46% (90% CI 0.12–0.80%), followed by 2.69% (90% CI 1.88–3.49%) in the second survey and 6.67% (90% CI 5.42–7.92%) in the third. The underreporting reached 11, 19.6, and 20.4 times in each survey. We observed increased odds to test positive in females compared to males (OR 1.88 95% CI 1.25–2.82), while the single best predictor for positivity was ageusia/anosmia (OR 8.12, 95% CI 4.72–13.98). Thirty-five SARS-CoV-2 genomes were sequenced, of which 18 were classified as lineage B.1.1.28, while 17 were B.1.1.33. Multiple independent viral introductions were observed. Integration of multiple epidemiological strategies was able to adequately describe COVID-19 dispersion in the city. Presented results have helped local government authorities to guide pandemic management.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fmicb.2022.799713/full

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