Lactation induces increases in theRANK/RANKL/OPG system in maxillary bone

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dc.creatorSoraia Macari
dc.creatorLavanya Ajay Sharma
dc.creatorAmanda Wyatt
dc.creatorJanine Mayra da Silva
dc.creatorGeorge Jayantha Dias
dc.creatorTarcília Aparecida da Silva
dc.creatorRaphael Escorsim Szawka
dc.creatorDavid Grattan
dc.date.accessioned2025-04-24T19:00:48Z
dc.date.accessioned2025-09-09T00:28:08Z
dc.date.available2025-04-24T19:00:48Z
dc.date.issued2018-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bone.2018.01.032
dc.identifier.issn1873-2763
dc.identifier.urihttps://hdl.handle.net/1843/81831
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBone
dc.rightsAcesso Restrito
dc.subjectBone remodeling
dc.subjectLactation
dc.subjectOsteoprotegerin
dc.subjectRANK ligand
dc.subjectReceptor activator of nuclear factor-kappa B
dc.subjectTooth movement techniques
dc.subjectOrthodontics
dc.subjectBone diseases, metabolic
dc.subjectDental implants
dc.subjectOsteoclasts
dc.subjectOsteoblasts
dc.subjectAlveolar bone loss
dc.subjectMaxilla
dc.subject.otherAlveolar bone
dc.subject.otherBone remodeling
dc.subject.otherLactation
dc.subject.otherOsteoprotegerin
dc.subject.otherRANK
dc.subject.otherRANKL
dc.titleLactation induces increases in theRANK/RANKL/OPG system in maxillary bone
dc.typeArtigo de periódico
local.citation.epage169
local.citation.spage160
local.citation.volume110
local.description.resumoThe underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodontic tooth movement (OTM). Micro-computed tomography (microCT) was performed in the maxilla, femur and vertebra. Tartrate-resistant-acid phosphatase (TRAP) and Masson's trichrome labelling was performed in the maxillary bone and gene expression was determined in the periodontal ligament. The effect of prolactin on osteoclast (OCL) and osteoblast (OBL) differentiation was also investigated in N-LAC and LAC mice. Lactation increased alveolar bone loss in the maxilla, femur and vertebra, while OTM was enhanced. The number of OCL and OBL was higher in the maxilla of LAC mice. OTM increased OCL in both groups; while OBL was increased only in N-LAC but not in LAC mice, in which cell numbers were already elevated. The alveolar bone loss during lactation was associated with increased expression of receptor activator of nuclear factor-KappaB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) in the maxilla. OTM induced the same responses in N-LAC mice, whereas it had no further effect in LAC mice. Lactation enhanced differentiation of OCL and OBL from bone marrow cells, and prolactin recapitulated OCL differentiation in N-LAC mice. Thus, lactation increases physiological maxillary bone remodeling and OTM, and both require activation of RANK/RANKL/OPG system. These findings expand our knowledge of lactation-induced osteopenia and have possible impact on clinical practice regarding orthodontic treatments and dental implants in lactating women.
local.identifier.orcidhttps://orcid.org/0000-0001-7643-6589
local.identifier.orcidhttps://orcid.org/0000-0002-8857-6340
local.identifier.orcidhttps://orcid.org/0000-0003-1107-3857
local.identifier.orcidhttps://orcid.org/0000-0003-3197-0061
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-2639-3469
local.identifier.orcidhttps://orcid.org/0000-0001-5606-2559
local.identifier.orcidhttps://orcid.org/0000-0002-1473-7455
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S8756328218300541?via%3Dihub

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