Is HIF1-a deregulated in malignant salivary neoplasms?

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dc.creatorCláudio Marcelo Cardoso
dc.creatorSabrina Ferreira de Jesus
dc.creatorMarcela Gonçalves de Souza
dc.creatorEloa Mangabeira Santos
dc.creatorCristiane Karine Cordeiro Santos
dc.creatorChristine Mendes Silveira
dc.creatorSergio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-29T13:43:28Z
dc.date.accessioned2025-09-08T23:34:25Z
dc.date.available2022-08-29T13:43:28Z
dc.date.issued2019-05-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.gene.2019.03.017
dc.identifier.issn0378-1119
dc.identifier.urihttps://hdl.handle.net/1843/44646
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGene
dc.rightsAcesso Aberto
dc.subjectTumores odontogênicos
dc.subjectCâncer - Quimioterapia
dc.titleIs HIF1-a deregulated in malignant salivary neoplasms?
dc.typeArtigo de periódico
local.citation.epage45
local.citation.spage41
local.citation.volume701
local.description.resumoBackground: there is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs). Objective: the current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms. Patients and methods: the current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR. Results: no differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups. Conclusion: the angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0378111919302434?via%3Dihub

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