Papel do eixo angiotensina-(1-7)-mas na função erétil

Abstract

The vasodilator/antiproliferative peptide angiotensin-(1-7) [Ang-(1-7)] is released into the corpus cavernosum sinuses, but its role on erectile function has not yet been defined. In this study we are reporting that Ang-(1-7) increases the erectile response induced by electrical stimulation of the major pelvic ganglion, and that this response is blockade by the Mas receptor antagonist, A-779. We documented the immunolocalization of the Ang-(1-7) receptor Mas, in human and rat corpus cavernosum. In addition, we observed that Ang-(1-7) induces nitric oxide release in human, rat and mouse corpus cavernosum, an effect that is absent in Mas-KO mice. More important, genetic deletion of Mas results in compromised erectile function as demonstrated by penile fibrosis and severely depressed response to electrical stimulation of the major pelvic ganglion. Furthermore, the attenuated erectile function of DOCA-salt hypertensive rats was fully restored by Ang-(1-7) administration. Altogether, these data provide strong evidence for a key role of the Ang-(1-7)-Mas axis in erectile function.