Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: an update

dc.creatorVivian Petersen Wagner
dc.creatorFelipe Paiva Fonseca
dc.creatorManoela Domingues Martins
dc.creatorCarla Isabelly Rodrigues-Fernandes
dc.creatorMarcus Vinícius Ribeiro Carvalho
dc.creatorJean Nunes dos Santos
dc.creatorMarinez Bizarro Barra
dc.creatorKeith Hunter
dc.creatorJose Manuel Aguirre-Urizar
dc.creatorWillie van Heerden
dc.creatorPablo Agustin Vargas
dc.date.accessioned2023-12-11T19:59:55Z
dc.date.accessioned2025-09-08T22:56:12Z
dc.date.available2023-12-11T19:59:55Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13214
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/61880
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of oral pathology & medicine
dc.rightsAcesso Aberto
dc.subjectLymphoma follicular
dc.subjectLeukemia, lymphocytic, chronic, B-Cell
dc.subjectLymphoma, B-Cell, marginal zone
dc.subjectLymphoma, Mantle-Cell
dc.subjectDiagnosis
dc.subjectPrognosis
dc.subjectMouth
dc.subject.otherLinfoma título periódico: Journal of oral pathology & medicine fao clínica
dc.subject.otherbusca dia 17 do 11 ano 2023
dc.titleMantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: an update
dc.typeArtigo de periódico
local.citation.epage630
local.citation.issue6
local.citation.spage622
local.citation.volume50
local.description.resumoBackground: Although uncommon, mature small B-cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. In this manuscript, we attempted to integrate the currently available data on the clinicopathological features of follicular lymphoma (FL), mantle cell lymphoma (MCL), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT-L), and chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) affecting these anatomical regions. Methods: An updated descriptive literature review was carried out and a detailed electronic search was done in multiple databases to gather all cases affecting the oral/maxillofacial region and palatine tonsils. Results: We observed that MALT-L was the most frequently reported subtype, followed by FL, MCL, and CLL/SLL. The palate was affected in a high proportion of cases and the most usual clinical presentation was an asymptomatic swelling. MALT-L and CLL/SLL neoplastic cells were strongly associated with small salivary glands. FL showed no gender preference, while MCL and CLL/SLL were more prevalent in males and MALT-L in females. Overall, cases were more common in elderly individuals. Patients' treatment and outcome varied, with MCL being the most aggressive neoplasm with a dismal prognosis in comparison to FL and MALT-L. Conclusion: Despite the poor documentation in many of the cases available, especially regarding the microscopic and molecular features of tumors, this review demonstrated that the oral mature small B-cell lymphomas investigated share similar clinical presentation, but carry different prognostic significance, demanding an accurate diagnosis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13214

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