Systematic review of reverse vaccinology and immunoinformatics data for non-viral sexually transmitted infections

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dc.creatorLucas Gabriel Rodrigues Gomes
dc.creatorJoyce C. F. Dutra
dc.creatorRodrigo Profeta
dc.creatorMariana V. Dias
dc.creatorGlen J. Y. García
dc.creatorDiego Lucas N. Rodrigues
dc.creatorAristóteles Goés Neto
dc.creatorFlávia F. Aburjaile
dc.creatorSandeep Tiwari
dc.creatorSiomar C. Soares
dc.creatorVasco Azevedo
dc.creatorArun K. Jaiswal
dc.date.accessioned2025-01-20T22:49:22Z
dc.date.accessioned2025-09-08T23:28:53Z
dc.date.available2025-01-20T22:49:22Z
dc.date.issued2023-08-27
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/0001-3765202320230617
dc.identifier.issn1678-2690
dc.identifier.urihttps://hdl.handle.net/1843/79344
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectVacina
dc.subjectDoenças sexualmente transmissíveis
dc.subjectImunologia
dc.subject.otherSexually transmitted infections
dc.subject.otherVaccinology
dc.subject.otherImmunoinformatics
dc.subject.otherVirtual drug screening
dc.subject.otherMulti-epitope vaccine
dc.titleSystematic review of reverse vaccinology and immunoinformatics data for non-viral sexually transmitted infections
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issueSuplemento 2
local.citation.spage1
local.citation.volume95
local.description.resumoSexually Transmitted Infections (STIs) are a public health burden rising in developed and developing nations. The World Health Organization estimates nearly 374 million new cases of curable STIs yearly. Global efforts to control their spread have been insufficient in fulfilling their objective. As there is no vaccine for many of these infections, these efforts are focused on education and condom distribution. The development of vaccines for STIs is vital for successfully halting their spread. The field of immunoinformatics is a powerful new tool for vaccine development, allowing for the identification of vaccine candidates within a bacterium’s genome and allowing for the design of new genome-based vaccine peptides. The goal of this review was to evaluate the usage of immunoinformatics in research focused on non-viral STIs, identifying fields where research efforts are concentrated. Here we describe gaps in applying these techniques, as in the case of Treponema pallidum and Trichomonas vaginalis.
local.identifier.orcidhttps://orcid.org/0000-0003-3769-7203
local.identifier.orcidhttps://orcid.org/0000-0003-2050-6706
local.identifier.orcidhttps://orcid.org/0000-0002-0487-3058
local.identifier.orcidhttps://orcid.org/0000-0001-8006-911X
local.identifier.orcidhttps://orcid.org/0000-0003-2062-5588
local.identifier.orcidhttps://orcid.org/0000-0003-2812-3072
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.identifier.orcidhttps://orcid.org/0000-0002-1067-1882
local.identifier.orcidhttps://orcid.org/0000-0002-8554-1660
local.identifier.orcidhttps://orcid.org/0000-0001-7299-3724
local.identifier.orcidhttps://orcid.org/0000-0002-4775-2280
local.identifier.orcidhttps://orcid.org/0000-0002-0558-483X
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/C9zxqNnp8BhM7cr7yc4qgHK/?lang=en

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