Tumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: a meta-analysis

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dc.creatorPatrícia Carlos Caldeira
dc.creatorAndrea María López Soto
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorCarolina de Castro Martins
dc.date.accessioned2024-04-09T18:34:53Z
dc.date.accessioned2025-09-09T01:20:27Z
dc.date.available2024-04-09T18:34:53Z
dc.date.issued2020-10
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1111/odi.13194
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/1843/66979
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Restrito
dc.subjectLymph nodes
dc.subjectMeta-analysis
dc.subjectMouth neoplasms
dc.subjectPrognosis
dc.subjectCarcinoma, squamous cell
dc.subject.otherLymph node
dc.subject.otherMeta‐analysis
dc.subject.otherOral cancer
dc.subject.otherPrognosis
dc.subject.otherSquamous cell carcinoma
dc.titleTumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: a meta-analysis
dc.typeArtigo de periódico
local.citation.epage1365
local.citation.issue7
local.citation.spage1357
local.citation.volume26
local.description.resumoObjectives: To assess the prognosis for early-stage oral squamous cell carcinoma according to tumor depth of invasion (DOI). Methods: This study was logged in the PROSPERO database under protocol # CRD42017059976. The search was conducted in six electronic databases up to May 2019. Fixed-effects meta-analysis was performed for the calculation of the odds ratio (OR) and respective 95% CI. Primary outcomes were lymph node metastasis, recurrence, and survival. Heterogeneity was calculated by the I2 test. The certainty of evidence was assessed by Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results: Twenty-seven studies were included (19 in the meta-analysis) with 2,404 patients with a mean of 60 years of age. High tumor DOI is associated with a greater chance of presenting lymph node metastasis, regardless of the cutoff point for DOI (13 meta-analysis; OR 1.69–53.08), recurrence (five meta-analysis; OR 1.22–3.83), and lower chance of survival (1 meta-analysis; OR 0.49). The certainty of evidence varied from very low to low. Conclusions: Tumor DOI is a good prognosticator for early-stage OSCC. The findings of the current meta-analysis highlight the clinical relevance of DOI and corroborate its incorporation for staging OSCC.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.13194

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