Improved antiproliferative activity of doxorubicin-loaded calcium phosphate nanoparticles against melanoma cells

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dc.creatorIgor Barbosa Lima
dc.creatorBetânia Mara Alvarenga
dc.creatorPriscila Izabel Santos de Tótaro
dc.creatorFernanda Boratto
dc.creatorElaine Amaral Leite
dc.creatorPedro Pires Goulart Guimaraes
dc.date.accessioned2025-02-04T16:48:11Z
dc.date.accessioned2025-09-09T00:09:00Z
dc.date.available2025-02-04T16:48:11Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-4324-2023220572
dc.identifier.issn1678-4324
dc.identifier.urihttps://hdl.handle.net/1843/79649
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.rightsAcesso Aberto
dc.subjectEnvelhecimento
dc.subjectBiologia celular e molecular
dc.subjectIndústria farmacêutica
dc.subjectEfeitos colaterais
dc.subjectFarmacoepidemiologia
dc.subject.otherSenescence
dc.subject.otherDrug delivery
dc.subject.otherCytotoxicity
dc.subject.otherA-375
dc.titleImproved antiproliferative activity of doxorubicin-loaded calcium phosphate nanoparticles against melanoma cells
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage01
local.citation.volume66
local.description.resumoThe high incidence of melanoma has received significant attention. Despite advances in early detection and standard treatment options, new strategies that improve therapy with reduced side effects are highly desirable. Several studies have demonstrated the efficiency of doxorubicin (Dox) to treat melanoma, however, side effects limit its clinical use. Drug delivery systems, especially nanostructured ones, are a useful approach to enhance antitumor activity and reduce toxicity of drugs. Here, the use of calcium phosphate nanoparticles functionalized with Dox and hyaluronic acid (N-Dox) to enhance Dox antiproliferative activity is reported. The effects were accessed in A-375 melanoma cells, in which N-Dox IC50 significantly decreased over 48 hours (0.14 ± 0.07 (M) compared to free drug (0.44 ± 0.25 (M) and showed selective action against A-375 when compared with HEK-293 cells. Treatment triggered DNA damage, increased nuclear area, and elicited senescent phenotype. Furthermore, it did not form colonies after 14 days of incubation preceded by short exposure treatment. These preliminary results indicate that N-Dox hold promise for melanoma treatment, reducing the minimum effective dose and perhaps a reduction in the cost of treatment.
local.identifier.orcidhttps://orcid.org/0000-0003-1171-5741
local.identifier.orcidhttps://orcid.org/0000-0002-6057-8280
local.identifier.orcidhttps://orcid.org/ 0000-0002-0102-5811
local.identifier.orcidhttps://orcid.org/0009-0008-6135-3383
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.identifier.orcidhttps://orcid.org/0000-0003-4534-2779
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/babt/a/w5rsZHLttqSPS5Gkhf8b7ZG/?lang=en

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