Phthalazine-triones: calix[4]arene-assisted synthesis using green solvents and their anticancer activities against human cancer cells

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dc.creatorYuri de Freitas Rego
dc.creatorCleiton Moreira da Silva
dc.creatorDaniel Leite da Silva
dc.creatorJeferson Jeferson Gomes
dc.creatorAna Lucia Tasca Gois Ruiz
dc.creatorJoão Ernesto de Carvalho
dc.creatorSergio Antonio Fernandes
dc.creatorÂngelo de Fátima
dc.date.accessioned2024-10-04T16:31:34Z
dc.date.accessioned2025-09-09T00:34:23Z
dc.date.available2024-10-04T16:31:34Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.arabjc.2016.04.007
dc.identifier.issn1878-5379
dc.identifier.urihttps://hdl.handle.net/1843/77226
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArabian Journal of Chemistry
dc.rightsAcesso Aberto
dc.subjectCompostos heterocíclicos
dc.subjectCatalise
dc.subjectMicroondas
dc.subjectCalixarenos
dc.subjectAgentes antineoplasicos
dc.subject.otherCatalysis
dc.subject.otherGreen chemistry
dc.subject.otherMicrowave assisted synthesis
dc.subject.otherAntiproliferative activity
dc.subject.otherp-Sulfonic acid calix[4]arene
dc.titlePhthalazine-triones: calix[4]arene-assisted synthesis using green solvents and their anticancer activities against human cancer cells
dc.typeArtigo de periódico
local.citation.epage4073
local.citation.issue8
local.citation.spage4065
local.citation.volume12
local.description.resumoFourteen phthalazine-triones bearing different substituents at C-4 position were synthesized through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent aldehydes as starting materials, p-sulfonic acid calix[4]arene as catalyst and ethyl lactate as solvent under microwave irradiation. Compounds 7–16 were obtained in excellent to moderate yields (94–51%) in only 10 min of reaction using this methodology. The antiproliferative activity against cancer cells was disclosed, for the first time, for synthesized compounds. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells. Compound 20 was active against more than one strain.
local.identifier.orcidhttps://orcid.org/0000-0003-4660-6852
local.identifier.orcidhttps://orcid.org/0000-0001-9913-8971
local.identifier.orcidhttps://orcid.org/0000-0002-3468-8478
local.identifier.orcidhttps://orcid.org/0000-0002-4219-1437
local.identifier.orcidhttps://orcid.org/0000-0002-0844-8702
local.identifier.orcidhttps://orcid.org/0000-0002-6901-6815
local.identifier.orcidhttps://orcid.org/0000-0003-3054-3316
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1878535216300314

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