Solitary fibrous tumour of the oral cavity: an update

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dc.creatorFernanda Bispo Nunes
dc.creatorMaria Sissa Pereira Sant'ana
dc.creatorAndré Myller Barbosa Silva
dc.creatorMichelle Agostini
dc.creatorNathalie Henriques Silva Canedo
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMário José Romañach
dc.creatorDavi Lavareda Corrêa
dc.creatorRamiro Alejandro Tomasi
dc.creatorRaghu Radhakrishnan
dc.creatorRicardo Santiago Gomez
dc.creatorSilvia Ferreira de Sousa
dc.creatorPeter A. Brennan
dc.creatorFelipe Paiva Fonseca
dc.date.accessioned2025-01-27T16:15:25Z
dc.date.accessioned2025-09-09T00:47:57Z
dc.date.available2025-01-27T16:15:25Z
dc.date.issued2020-01
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12953
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/79496
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectHemangiopericytoma
dc.subjectMouth
dc.subjectMicroscopy
dc.subjectImmunohistochemistry
dc.subjectClinical study
dc.subjectMouth mucosa
dc.subjectTongue
dc.subjectNeoplasms
dc.subjectSurgical oncology
dc.subject.otherNAB2-STAT6
dc.subject.otherSTAT6
dc.subject.otherHemangiopericytoma
dc.subject.otherOral cavity
dc.subject.otherSolitary fibrous tumour
dc.titleSolitary fibrous tumour of the oral cavity: an update
dc.typeArtigo de periódico
local.citation.epage20
local.citation.issue1
local.citation.spage14
local.citation.volume49
local.description.resumoBackground: Solitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature. Methods: For our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database. Results: A total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well-circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported. Conclusion: Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.
local.identifier.orcidhttps://orcid.org/0000-0003-0088-4777
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-4804-3264
local.identifier.orcidhttps://orcid.org/0000-0002-6657-4547
local.identifier.orcidhttps://orcid.org/0000-0002-0199-1884
local.identifier.orcidhttps://orcid.org/0000-0001-9524-4638
local.identifier.orcidhttps://orcid.org/0000-0002-3648-337X
local.identifier.orcidhttps://orcid.org/0000-0002-3259-606X
local.identifier.orcidhttps://orcid.org/0000-0002-7853-5916
local.identifier.orcidhttps://orcid.org/0000-0001-7378-4086
local.identifier.orcidhttps://orcid.org/0000-0003-2705-8221
local.publisher.countryBrasil
local.publisher.departmentFAO - FACULDADE DE ODONTOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12953

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