CD30 expression in oral and oropharyngeal diffuse large b cell lymphoma, not otherwise specified
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Diffuse large B cell lymphoma, not otherwise specified (DLBCL, NOS) is the most frequent non-Hodgkin lymphoma subtype. This aggressive neoplasm may variably express the CD30 protein, which may be used as a therapeutic target for this tumor. However, CD30 expression in DLBCL NOS arising from the oral cavity and the oropharynx has not been investigated. Therefore, this study aims to determine the frequency of CD30 expression and its prognostic significance for patients affected by oral/oropharyngeal DLBCL NOS. Fifty cases were retrieved from pathology files and submitted to immunohistochemistry against CD30. Reactivity was accessed by two oral pathologists using two cut-off values (> 0% and > 20% of tumor cells) to determine positivity in each case. Clinical data were obtained from the patients' medical files to investigate the prognostic potential of the protein. Seven high-grade B cell lymphomas and two EBV-positive DLBCL NOS were identified. We found one CD30-positive case in each of these two groups of lymphomas. Among the remaining 41 DLBCL NOS, other four cases (three in the oral cavity and one in the oropharynx) were positive for CD30, but only two expressed the protein in > 20% of tumor cells, both in the oral cavity. Survival analysis demonstrated that CD30-positive cases had a higher five-year overall survival rate (75%) than CD30-negative cases (32.3%), although a statistically significant result was not achieved (p = 0.19). Only a minor subset of oral and oropharyngeal DLBCL NOS express CD30 and these patients seems to have a higher survival rate.
Abstract
Assunto
Ki-1 antigen, Lymphoma, Lymphoma, large B-Cell, diffuse, Head, Neck, Mouth, Oropharynx, Survival rate, Immunohistochemistry
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acesso restrito springer fao clínica Cd30 expression in oral and oropharyngeal diffuse large b cell lymphoma, not otherwise specified assunto Lymphoma busca dia 09 do 11 2023, título periódico Head and neck pathology data 16 outubro ano 2021
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https://link.springer.com/article/10.1007/s12105-021-01387-5