Epigenetic-Induced Production of Promising Food Supplements Ingredients with Antioxidant and Anti-Acetylcholinesterase Activities

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dc.creatorLaura Dominguete
dc.creatorPaulo Lima
dc.creatorIsabela Nunes
dc.creatorDenise Sande Santos
dc.creatorUbiraci Gomes de Paula Lana
dc.creatorIvanildo Marriel
dc.creatorJacqueline Aparecida Takahashi
dc.date.accessioned2023-10-18T20:46:29Z
dc.date.accessioned2025-09-08T23:20:00Z
dc.date.available2023-10-18T20:46:29Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3303/CET1975056
dc.identifier.issn2283-9216
dc.identifier.urihttps://hdl.handle.net/1843/59649
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical Engineering Transactions
dc.rightsAcesso Aberto
dc.subjectCiência e Tecnologia de Alimentos
dc.subjectQuímica
dc.subject.otherCiência e Tecnologia de Alimentos
dc.subject.otherQuímica
dc.titleEpigenetic-Induced Production of Promising Food Supplements Ingredients with Antioxidant and Anti-Acetylcholinesterase Activities
dc.typeArtigo de periódico
local.citation.epage336
local.citation.spage331
local.citation.volume75
local.description.resumoFungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed as food supplements helpful for treatment of neurodegenerative diseases, like Alzheimer's disease. Fungal biosynthesis depends on the expression of several enzymes that can change chromatin’s conformation, provoking activation or silencing of gene transcription. In this sense, the use of epigenetic modulators, able to alter chromatin’s conformation, has been a modern technique used to induce the expression of silenced genes in fungi. In the present study the metabolic profile and the antioxidant and anti-acetylcholinesterase activities of the extracts of Penicillium flavigenum (PF) and P. tanzanicum (PT) grown in the presence of epigenetic modulators were analyzed. The fungi were grown in liquid media, with or without (control) the epigenetic modulators azacytidine (AZA), hydralazine (HYDRA), procainamide (PRO), suberoyl hydroxamic acid (SAHA) and sodium butyrate (BUT) (500 μM). The modulators changed the expression of exogenous metabolites produced by the fungi with overexpression of some compounds in comparison to the controls, according to the HPLC chromatographic profiles. The treatment PF-SAHA presented the higher content of total phenolic compounds (27.86 mg GAE/g) (together with PF-HYDRA and PF-BUT) and the higher total antioxidant content (25.70 mg AAE/g). Besides, PF-SAHA and PF-PRO extracts presented higher antiacetylcholinesterase activity compared to others extracts. AZA was one of the most effective treatments for increasing expression of metabolites with antioxidant activity by P. tanzanicum in at least half of the assays. Treatments PT-AZA, PT-HYDRA and PT-BUT showed statistically similar anti-acetylcholinesterase activity, which were superior to the activity of the fungal control (15%). In overall, fermentative conditions using PFSAHA and PF-PRO showed to be the most favorable to produce new bioactive metabolites to be used as food supplements for palliative treatment or prevention of Alzheimer’s disease, while complete cure is not possible so far.
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.aidic.it/cet/19/75/056.pdf

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