Expression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women

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dc.creatorOrcione Ferreira Guimarães Júnior
dc.creatorGabriel Ledo Pereira de Oliveira
dc.creatorDeborah de Farias Lelis
dc.creatorThaís de Oliveira Faria Baldo
dc.creatorMarcelo Perim Baldo
dc.creatorSergio Henrique Sousa Santos
dc.creatorJoão Marcus Oliveira Andrade
dc.date.accessioned2025-08-05T16:22:52Z
dc.date.accessioned2025-09-09T00:07:44Z
dc.date.available2025-08-05T16:22:52Z
dc.date.issued2024-10-23
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1080/1354750X.2024.2411346
dc.identifier.issn1366-5804
dc.identifier.urihttps://hdl.handle.net/1843/84041
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectGrávidas
dc.subjectObesidade em mulheres
dc.subjectSistema renina-angiotensina
dc.subjectTecido adiposo
dc.subjectPlacenta
dc.titleExpression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women
dc.typeArtigo de periódico
local.citation.epage441
local.citation.issue7
local.citation.spage434
local.citation.volume29
local.description.resumoBackground: this study evaluated the expression of ACE and ACE2 in the placenta and white adipose tissue in lean and obese women, and correlated their levels with anthropometric, clinical, and laboratory parameters, and tissue count of inflammatory cells. Methods: a cross-sectional analytical study was performed with 49 pregnant women and their respective newborns. Samples of placenta and adipose tissue were used for measuring mRNA expression for ACE and ACE2 through qRT-PCR. Inflammatory cell counting was performed through conventional microscopy. Results: an increase in ACE expression and a decrease in ACE2 were observed in the placenta and adipose tissue of women with obesity. ACE2 levels showed a negative correlation with pre-pregnancy BMI and total cholesterol. Conclusion: maternal obesity can modulate the expression of RAS components in the placenta and white adipose tissue, with ACE2 correlated with pre-pregnancy BMI and total cholesterol.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/full/10.1080/1354750X.2024.2411346

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