Acosmium dasycarpum (Vog.) Yakovlev root bark reduces obesity induced by hypercaloric diet in mice: acosmium dasycarpum improves obesity

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dc.creatorDaniela Fernanda de Freitas
dc.creatorSérgio Henrique Sousa Santos
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorLuciana Mendes Araújo Borém
dc.creatorValéria Mafra
dc.creatorDiego Vicente da Costa
dc.creatorTheles Oliveira Costa
dc.creatorClaudia Regina Vieira
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2023-03-30T12:53:09Z
dc.date.accessioned2025-09-08T23:44:07Z
dc.date.available2023-03-30T12:53:09Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.phytol.2021.04.014
dc.identifier.issn1874-3900
dc.identifier.urihttps://hdl.handle.net/1843/51362
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhytochemistry Letters
dc.rightsAcesso Restrito
dc.subjectPlantas medicinais
dc.subjectObesidade
dc.subjectFígado gorduroso
dc.subjectDiabetes
dc.titleAcosmium dasycarpum (Vog.) Yakovlev root bark reduces obesity induced by hypercaloric diet in mice: acosmium dasycarpum improves obesity
dc.typeArtigo de periódico
local.citation.epage30
local.citation.spage23
local.citation.volume44
local.description.resumoAcosmium dasycarpum (Vog.) Yakovlev, is a Brazilian medicinal plant, belonging to the Fabaceae family known as "Unha D’anta", exclusively found in the Cerrado (Brazilian Savanna) region, and has already shown tranquilizing, hypotensive, antineoplastic and antiseptic activities reported by traditional medicine and scientific evidences. Considering that overweight and obesity are an increasing worldwide health problem, the present study aimed to investigate the anti-obesity effect of bark powder and the dichloromethane extract of A. dasycarpum compared to the most abundant bioactive component (lupeol) using an obese mice model induced by a high-fat diet (HFD). The extracts derived from root bark of A. dasycarpum were characterized (phytochemical screening and GC–MS analysis) and their biological effects tested. After obesity inducement, Swiss male mice were treated with bark root powder or dichloromethane extract or lupeol (all treatments with 10 mg/1000 g/body weight dose) during 14 days. Oral glucose tolerance, insulin sensitivity, lipid profile, histology, ultrasound imaging and adipogenic genes expression were evaluated. The main results showed that A. dasycarpum root bark powder and dichloromethane extract reduced body weight and adiposity as evidenced by histology and ultrasound imaging. We also verified an improved glycemic and lipid profiles by reducing triglycerides, LDL and increasing HDL. The A. dasycarpum treatment suppressed the expression of CCAAT/enhancer-binding protein (C/EBPα), fatty acid translocase (FAT), and stearoyl coenzyme A desaturase-1 (SCD-1) adipogenic genes when compared to the obese control group. In conclusion, A. dasycarpum root bark showed a potential to be an accessible adjuvant treatment for obesity.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1874390021000926?via%3Dihub

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