Preparation of magnetoliposomes with a green, low-cost, fast and scalable methodology and activity study against s. aureus and c. freundii bacterial strains

Página do item simplificado
dc.creatorRosangela Maria Ferreira da Costa e Silva
dc.creatorLuciano Roni Silva Lara
dc.creatorJorge Luis López Aguilar
dc.creatorÂngela Leão Andrade
dc.creatorJunnia Alvarenga de Carvalho Oliveira
dc.creatorJacqueline Aparecida Takahashi
dc.creatorHenriete da Silva Vieira
dc.creatorTulio Matencio
dc.creatorHumberto Osório Stumpf
dc.creatorRosana Zacarias Domingues
dc.date.accessioned2023-08-08T15:04:03Z
dc.date.accessioned2025-09-08T23:55:53Z
dc.date.available2023-08-08T15:04:03Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.21577/0103-5053.20180144
dc.identifier.issn1678-4790
dc.identifier.urihttps://hdl.handle.net/1843/57605
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectBioquímica
dc.subjectMateriais magnéticos
dc.subjectNanopartículas
dc.subjectLecitina
dc.subjectMagnetita
dc.subjectLipossomos
dc.subjectMicroscopia eletrônica
dc.subjectRessonância magnética nuclear
dc.subjectFourier, Espectroscopia de infravermelho por transformada de
dc.subjectRaios X — Difração
dc.subjectLuz — Espalhamento
dc.subjectPotencial zeta
dc.subjectAgentes antibacterianos
dc.subject.otherSoy lecithin
dc.subject.otherMagnetite
dc.subject.otherLiposomes
dc.subject.otherStaphylococcus aureus
dc.subject.otherCitrobacter freundii
dc.titlePreparation of magnetoliposomes with a green, low-cost, fast and scalable methodology and activity study against s. aureus and c. freundii bacterial strains
dc.typeArtigo de periódico
local.citation.epage2645
local.citation.issue12
local.citation.spage2636
local.citation.volume29
local.description.resumoA novel, fast, low-cost and scalable methodology to prepare stable magnetoliposomes (MGLs), without the use of organic solvents, is described. The concept of the work is based on the dual use of soy lecithin associated to a new liposome preparation methodology. Soy lecithin was used to coat the nanoparticles of magnetite (Fe3O4@lecithin) and for encapsulation of Fe3O4@lecithin (Lip-Fe3O4@lecithin). Liposomes with size less than 160 nm, polydispersity index of 0.25 and zeta potential of –41 mV, were prepared with the use of autoclave and sonication. The liposomal formulations containing magnetite and stigmasterol (Lip-Fe3O4@lecithin, Lip-Stigma and Lip‑Stigma-Fe3O4@lecithin) were shown to be promising for the application as antibacterial. The liposomal formulation and magnetite were characterized by the following techniques: conventional and high-resolution transmission electron microscopy (TEM/HRTEM), energy-filtered transmission electron microscopy (EFTEM), proton nuclear magnetic resonance (1H NMR), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), dynamic light scattering (DLS) and zeta potential. The Lip-Fe3O4@lecithin had a minimum inhibitory concentration (MIC) of 8.4 μg mL-¹ in the presence of 200 Oe magnetic field against S. aureus.
local.identifier.orcidhttps://orcid.org/0000-0002-6792-2558
local.identifier.orcidhttps://orcid.org/0000-0003-0749-1351
local.identifier.orcidhttps://orcid.org/0000-0002-0888-5072
local.identifier.orcidhttps://orcid.org/0000-0001-5023-0881
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.identifier.orcidhttps://orcid.org/0000-0002-4303-2665
local.identifier.orcidhttps://orcid.org/0000-0002-5660-8125
local.identifier.orcidhttps://orcid.org/0000-0001-7756-0987
local.identifier.orcidhttps://orcid.org/0000-0001-5667-2031
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://jbcs.sbq.org.br/audiencia_pdf.asp?aid2=5367&nomeArquivo=2018-0154AR.pdf

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Preparation of magnetoliposomes with a green, low-cost, fast and scalable methodology and activity study against s. aureus and c. freundii bacterial strains.pdf
Tamanho:
2.55 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG