Antimicrobial resistance of microorganisms present in periodontal diseases: a systematic review and meta-analysis

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dc.creatorFlávia Casale Abe
dc.creatorKatia Kodaira
dc.creatorCristiane de Cássia Bergamaschi Motta
dc.creatorSilvio Barberato-Filho
dc.creatorMarcus Tolentino Silva
dc.creatorCaio Chaves Guimarães
dc.creatorCarolina de Castro Martins
dc.creatorLuciane Cruz Lopes
dc.date.accessioned2024-05-07T20:17:03Z
dc.date.accessioned2025-09-09T01:13:02Z
dc.date.available2024-05-07T20:17:03Z
dc.date.issued2022-10
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.961986
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/1843/68120
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Microbiology
dc.rightsAcesso Aberto
dc.subjectAnti-bacterial agents
dc.subjectDentistry
dc.subjectEndodontics
dc.subjectDrug resistance
dc.subjectAnti-infective agents
dc.subjectPeriodontics
dc.subject.otherAnti-bacterial agents
dc.subject.otherDentistry
dc.subject.otherEndodontics
dc.subject.otherDrug resistance
dc.subject.otherMicrobial
dc.subject.otherPeriodontics
dc.titleAntimicrobial resistance of microorganisms present in periodontal diseases: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.spage961986
local.citation.volume13
local.description.resumoObjective: The aim of this study was to estimate the antimicrobial resistance in microorganisms present in periodontal diseases. Methods: A systematic review was conducted according to the PRISMA statement. The MEDLINE (PubMed/Ovid), EMBASE, BVS, CINAHL, and Web of Science databases were searched from January 2011 to December 2021 for observational studies which evaluated the antimicrobial resistance in periodontal diseases in permanent dentition. Studies that allowed the antimicrobial consumption until the time of sample collection, studies that used laboratory acquired strains, studies that only characterized the microbial strain present, assessment of cellular morphological changes, sequencing system validation, and time series were excluded. Six reviewers, working in pairs and independently, selected titles, abstracts, and full texts extracting data from all studies that met the eligibility criteria: characteristics of patients, diagnosis of infection, microbial species assessed, antimicrobial assessed, identification of resistance genes, and virulence factors. “The Joanna Briggs Institute” critical appraisal for case series was adapted to assess the risk of bias in the included studies. Results: Twenty-four studies (N = 2.039 patients) were included. Prevotella and Porphyromonas species were the most cited microorganisms in the included studies, and the virulence factors were related to Staphylococcus aureus. The antimicrobial reported with the highest frequency of resistance in the included studies was ampicillin (39.5%) and ciprofloxacin showed the lowest frequency of resistance (3.4%). The most cited genes were related to macrolides. The quality of the included studies was considered critically low. Conclusion: No evidence was found regarding the profile of antimicrobial resistance in periodontal diseases, requiring further research that should focus on regional population studies to address this issue in the era of increasing antimicrobial resistance. Clinical relevance: The knowledge about the present microorganism in periodontal diseases and their respective antimicrobial resistance profiles should guide dentists in prescribing complementary therapy for these infections.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.961986/full

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