Clinicopathological analysis of oral burkitt's lymphoma in pediatric patients: a systematic review
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Universidade Federal de Minas Gerais
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The aim of this study was to integrate the available data regarding pediatric Burkitt's lymphoma (BL) of the oral cavity. A systematic review was conducted following PRISMA guidelines, through a specific search strategy. Twenty-nine publications were included in this study, resulting in a total of 144 cases. Oral BL was predominantly found in males (75.7%). The mandible was the most involved site (37.5%), and all cases clinically exhibited a swelling. Presence of EBV was observed in 33.3% of the cases, and 4 cases reported HIV-positive patients (33.3%). Chemotherapy was the leading treatment choice for oral BL (94.9%), and the overall 5-year survival was 54.3%. Regarding the quality assessment of the studies, most (19 studies; 65.5%) were classified as an overall moderate risk of bias. In conclusion, the clinicopathological characteristics of oral BL in the pediatric population comprise the sporadic and intermediate subtypes. Despite its aggressiveness, this malignancy presents a moderate overall survival.
Abstract
Assunto
Burkitt lymphoma, Mandible, Maxilla, Mouth, Edema, Neoplasms, Drug therapy
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título periódico: International journal of pediatric otorhinolaryngology, acesso restrito fao clinica Clinicopathological analysis of oral burkitt's lymphoma in pediatric patients: a systematic review assunto Burkitt Lymphoma busca dia 25 do 10 2023
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https://www.sciencedirect.com/science/article/pii/S0165587620301762?via%3Dihub