Lipoxin A4 is increased in the plasma of preeclamptic women

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dc.creatorLuiza Oliveira Perucci
dc.creatorPatrícia Campi Santos
dc.creatorLucas Secchim Ribeiro
dc.creatorDanielle da Glória de Souza
dc.creatorKarina Braga Gomes Borges
dc.creatorLuci Maria SantAna Dusse
dc.creatorLirlândia Pires de Sousa
dc.date.accessioned2022-03-16T19:46:18Z
dc.date.accessioned2025-09-09T01:19:31Z
dc.date.available2022-03-16T19:46:18Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1093/ajh/hpw053
dc.identifier.issn1941-7225
dc.identifier.urihttps://hdl.handle.net/1843/40165
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAmerican Journal of Hypertension
dc.rightsAcesso Aberto
dc.subjectPressão sanguínea
dc.subjectHipertensão
dc.subjectInflamação
dc.subjectLipoxinas
dc.subjectPré-eclâmpsia
dc.subjectComplicações na gravidez
dc.subject.otherBlood pressure
dc.subject.otherHypertension
dc.subject.otherInflammation
dc.subject.otherLipoxin A4
dc.subject.otherPreeclampsia
dc.subject.otherResolution
dc.titleLipoxin A4 is increased in the plasma of preeclamptic women
dc.typeArtigo de periódico
local.citation.epage1185
local.citation.issue10
local.citation.spage1179
local.citation.volume29
local.description.resumoBackground: Excessive inflammation is involved in preeclampsia (PE) pathogenesis. Lipoxin A4 (LXA4) is an eicosanoid that counter-regulates inflammation. The main objective of this study was to determine LXA4 plasma levels in PE women. The correlations among LXA4 levels, ultrasensitive C-reactive protein (us-CRP) levels, and clinical/laboratory parameters of the studied participants were also investigated. Methods: LXA4 plasma levels were determined by ELISA in 23 nonpregnant, 26 normotensive pregnant, and 27 PE women (early PE (N = 10) and late PE (N = 17)), according to gestational age (GA) at clinical symptoms onset). The clinical/laboratory parameters included in Spearman's correlation analysis were: systolic and diastolic blood pressure (SBP and DBP, respectively), lactate dehydrogenase (LDH) activity, platelet count, proteinuria, and white blood cell count (WBC). Results: LXA4 levels were higher in PE women than in nonpregnant and normotensive pregnant women, and similar between nonpregnant and normotensive pregnant women. LXA4 plasma levels were higher in early PE vs. normotensive pregnancy (GA < 34 weeks) and in late PE vs. normotensive pregnancy (GA ≥ 34 weeks). No significant differences were detected between early and late PE. LXA4 levels were positively correlated with us-CRP levels, SBP, DBP, and WBC. No significant correlation was detected between LXA4 levels and the other laboratory parameters. Conclusions: Chronic inflammation in PE, in spite of increased levels of LXA4, points to a possible failure in this regulatory pathway. Further studies are necessary to clarify this issue and to evaluate the role of LXA4 and other proresolving mediators of inflammation in the pathogenesis of PE.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/ajh/article/29/10/1179/2622235?login=false

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